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  1. Article

    Open Access

    The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis

    Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a prot...

    **** Xu, Lei Zhou, Lei Ji, Fengyuan Chen, Karen Fortmann… in Nature Communications (2016)

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  2. No Access

    Article

    Alternative pathways for the selection of antigen-specific peripheral T cells

    IN the thymus, maturing lymphocytes receive activation signals mediated by the T-cell antigen receptor (TCR) that either promote clonal survival (positive selection) or induce apoptosis (negative selection). T...

    Biao Zheng, Shuhua Han, Qing Zhu, Richard Goldsby, Garnett Kelsoe in Nature (1996)

  3. Article

    Hypermutation in T cells questioned

    Garnett Kelsoe, Biao Zheng, Thomas B. Kepler in Nature (1995)

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    Article

    Locus-specific somatic hypermutation in germinal centre T cells

    SOMATIC hypermutation and affinity-driven selection of active immunoglobulin genes occur in germinal centres (GCs), resulting in the generation of high-affinity memory B cells1–3. In contrast, T lymphocytes do no...

    Biao Zheng, Wei Xue, Garnett Kelsoe in Nature (1994)