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Article
Open AccessImpaired metal perception and regulation of associated human foliate papillae tongue transcriptome in long-COVID-19
Chemosensory impairment is an outstanding symptom of SARS-CoV-2 infections. We hypothesized that measured sensory impairments are accompanied by transcriptomic changes in the foliate papillae area of the tongu...
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Article
Open AccessEndothelial dysfunction in retinal vessels of hemodialysis patients compared to healthy controls
Endothelial dysfunction is a key factor promoting atherosclerosis and cardiovascular complications. Hemodialysis patients typically show various cardiovascular complications and impaired retinal venular dilati...
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Article
Open AccessReduced tear fluid production in neurological diseases: a cohort study in 708 patients
Tear fluid (TF) production is an important component of normal ocular function. It is regulated by parasympathetic and sympathetic innervation. Because parasympathetic nerve fibers originate in the brainstem, ...
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Article
Open AccessCOVID-19 in Female and Male Athletes: Symptoms, Clinical Findings, Outcome, and Prolonged Exercise Intolerance—A Prospective, Observational, Multicenter Cohort Study (CoSmo-S)
An infection with SARS-CoV-2 can lead to a variety of symptoms and complications, which can impair athletic activity.
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Article
Open AccessAuthor Correction: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
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Article
Open AccessEndovascular aortic repair with sac embolization for the prevention of type II endoleaks (the EVAR-SE study): study protocol for a randomized controlled multicentre study in Germany
Beyond a certain threshold diameter, abdominal aortic aneurysms (AAA) are to be treated by open surgical or endovascular aortic aneurysm repair (EVAR). In a quarter of patients who undergo EVAR, inversion of b...
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Article
Open AccessStudent mistakes and teacher reactions in bedside teaching
We analyse interactions between teachers and students during video-recorded bedside teaching sessions in internal medicine, orthopaedics and neurology. Multiple raters used a high-inference categorical scheme ...
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Article
Open AccessAssessment of glenoid bone loss and other osseous shoulder pathologies comparing MR-based CT-like images with conventional CT
To evaluate and compare the diagnostic performance of CT-like images based on a 3D T1-weighted spoiled gradient-echo sequence (T1 GRE), an ultra-short echo time sequence (UTE), and a 3D T1-weighted spoiled mul...
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Article
Open AccessPlatelet aggregates detected using quantitative phase imaging associate with COVID-19 severity
The clinical spectrum of acute SARS-CoV-2 infection ranges from an asymptomatic to life-threatening disease. Considering the broad spectrum of severity, reliable biomarkers are required for early risk stratifi...
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Article
Open AccessCorrection: Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
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Open AccessPersistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation
Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of...
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Article
Open AccessTrans-fatty acid blood levels of industrial but not natural origin are associated with cardiovascular risk factors in patients with HFpEF: a secondary analysis of the Aldo-DHF trial
Industrially processed trans-fatty acids (IP-TFA) have been linked to altered lipoprotein metabolism, inflammation and increased NT-proBNP. In patients with heart failure with preserved ejection fraction (HFpE...
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Article
Open AccessProteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
Systemic pan-tumor analyses may reveal the significance of common features implicated in cancer immunogenicity and patient survival. Here, we provide a comprehensive multi-omics data set for 32 patients across...
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Article
Open AccessThe synovial fluid calprotectin lateral flow test for the diagnosis of chronic prosthetic joint infection in failed primary and revision total hip and knee arthroplasty
The diagnostic criteria of prosthetic joint infection (PJI) recommended by the most commonly used diagnostic algorithms can be obscured or distorted by other inflammatory processes or aseptic pathology. Furth...
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Article
Open AccessDark-field chest X-ray imaging for the assessment of COVID-19-pneumonia
Currently, alternative medical imaging methods for the assessment of pulmonary involvement in patients infected with COVID-19 are sought that combine a higher sensitivity than conventional (attenuation-based) ...
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Article
Open AccessPlanning preclinical confirmatory multicenter trials to strengthen translation from basic to clinical research – a multi-stakeholder workshop report
Clinical translation from bench to bedside often remains challenging even despite promising preclinical evidence. Among many drivers like biological complexity or poorly understood disease pathology, preclinic...
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Article
Cardiovascular outcome of former late-onset small-for-gestational-age children at 1 year of age: CURIOSA study
Late-onset small-for-gestational-age (SGA) fetuses usually show normal uterine artery Doppler and were long considered to have a good peri- and postnatal outcome. Recently, these fetuses were identified to hav...
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Article
Open AccessA randomized prospective cross over study on the effects of medium cut-off membranes on T cellular and serologic immune phenotypes in hemodialysis
Extended cut-off filtration by medium cut-off membranes (MCO) has been shown to be safe in maintenance hemodialysis (HD). The notion of using them for the control of chronic low-grade inflammation and positive...
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Article
Open AccessPredictive value of clinical and 18F-FDG-PET/CT derived imaging parameters in patients undergoing neoadjuvant chemoradiation for esophageal squamous cell carcinoma
Aim of this study was to validate the prognostic impact of clinical parameters and baseline 18F-FDG-PET/CT derived textural features to predict histopathologic response and survival in patients with esophageal sq...
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Article
Open AccessEarly reduction of SARS-CoV-2-replication in bronchial epithelium by kinin B2 receptor antagonism
SARS-CoV-2 has evolved to enter the host via the ACE2 receptor which is part of the kinin-kallikrein pathway. This complex pathway is only poorly understood in context of immune regulation but critical to cont...
