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Article
Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues
The fundamental question posed here is why in dorsal root ganglia herpes simplex viruses (HSV) can establish a silent infection in which only latency associate transcripts (LAT) and miRNAs are expressed and th...
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Article
Open AccessThe novel HSV-1 US5-1 RNA is transcribed off a domain encoding US 5, US 4, US 3, US 2 and α22
The genome of herpes simplex virus 1 encodes at least 84 transcripts from which proteins are translated and several additional RNAs whose status as mRNAs is unknown. These RNAs include latency-associated trans...
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Article
The order Herpesvirales
The taxonomy of herpesviruses has been updated by the International Committee on Taxonomy of Viruses (ICTV). The former family Herpesviridae has been split into three families, which have been incorporated into t...
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Article
Open AccessAntisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA
Human papillomavirus (HPV) infection is known to be the most important etiologic factor of cervical cancer. There is no HPV specific therapy available for treatment of invasive squamous cell carcinoma of the c...
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Chapter
The Strategy of Conquest
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Chapter
Evasion and Obstruction
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Reference Work Entry In depth
Simplexvirus
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Protocol
Analyses of HSV Proteins for Posttranslational Modifications and Enzyme Functions
In order to identify the nature of posttranslational modifications and enzyme functions of herpes simplex virus 1 and 2 (HSV-1 and HSV-2) proteins, it is necessary to apply both biochemical and genetic analyse...
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Chapter
Herpes Simplex Viruses, Central Nervous System, and Encephalitis
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are genetically related, ubiquitous human pathogens. The viruses are transmitted from person to person by direct contact of infected tissues containing virus wi...
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Chapter
Molecular biology of herpes simplex virus
Herpes . . . in the current post sexual-revolution era is certainly a familiar term yet the virus responsible is truly ancient. Indeed, herpes simplex virus has been with us for far longer than we have been Homo ...
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Book
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Chapter
Whither Herpesviruses
Viruses have been described as computer cartridges in search of a computer. The comparison may at least for the moment exaggerate the power of computers, but the resemblance is not altogether all that bad: the...
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Chapter and Conference Paper
Genetic Engineering and Properties of Novel Herpes Simplex Viruses for Use as Potential Vaccines and as Vectors of Foreign Genes
The pathology associated with viral infections as well as the attempts to prevent them are closely dependent on the biology of virus-host interactions. A unique feature of herpes simplex viruses 1 and 2 (HSV-1...
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Chapter
Herpes Virus Vectors
The size, structure, and wide host range of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) make them suitable for use as vectors of genetic material both their own and that of foreign genomes. This chapter w...
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Chapter
Herpesviruses: Biology, Gene Regulation, Latency, and Genetic Engineering
The family Herpesviridae includes a large number of structurally related DNA viruses classified on the basis of the architecture of the virion (1). Their hosts range from lower vertebrates to primates, and many s...
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Book
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Book
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Book
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Chapter
Restriction Endonuclease Patterns of Herpes Simplex Virus DNA: Application to Diagnosis and Molecular Epidemiology
Historically, the indications that herpes simplex virus (HSV) strains may vary considerably emerged many years ago (Ashe and Scherp 1965; Hampar and Burroughs 1969). For one of us (BR), the studies on the variabi...
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Book
