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  1. Article

    Open Access

    Spike deep mutational scanning helps predict success of SARS-CoV-2 clades

    SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion1 and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and cell entry2,3. Knowledge of ...

    Bernadeta Dadonaite, Jack Brown, Teagan E. McMahon, Ariana G. Farrell… in Nature (2024)

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  2. Article

    Open Access

    Computationally restoring the potency of a clinical antibody against Omicron

    The COVID-19 pandemic underscored the promise of monoclonal antibody-based prophylactic and therapeutic drugs1–3 and revealed how quickly viral escape can curtail effective options4,5. When the SARS-CoV-2 Omicron...

    Thomas A. Desautels, Kathryn T. Arrildt, Adam T. Zemla, Edmond Y. Lau… in Nature (2024)

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  3. Article

    The structure of the influenza A virus genome

    Influenza A viruses (IAVs) constitute a major threat to human health. The IAV genome consists of eight single-stranded viral RNA segments contained in separate viral ribonucleoprotein (vRNP) complexes that are...

    Bernadeta Dadonaite, Brad Gilbertson, Michael L. Knight… in Nature Microbiology (2019)

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