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Article
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
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Article
Open AccessSex differences and individual variability in the captive Jamaican fruit bat (Artibeus jamaicensis) intestinal microbiome and metabolome
The intestinal microbiome plays an important role in mammalian health, disease, and immune function. In light of this function, recent studies have aimed to characterize the microbiomes of various bat species,...
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Article
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
Preserving cells in a functional, non-senescent state is a major goal for extending human healthspans. Model organisms reveal that longevity and senescence are genetically controlled, but how genes control lon...
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Chapter and Conference Paper
Experiencing Ethics and Values in the Design Process of AI-Enabled Medical Devices and Software
The interaction design of medical devices has to engage and cater to the needs of a wide range of stakeholders, from patients to physicians. The present paper aims to show by example the methodological integr...
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Article
Open AccessFibre optic distributed acoustic sensing of volcanic events
Understanding physical processes prior to and during volcanic eruptions has improved significantly in recent years. However, uncertainties about subsurface structures distorting observed signals and undetected...
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Article
Open AccessNeuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived fr...
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Article
Open AccessInfluence of compounding conditions, treatment of wood particles with fire-retardants and artificial weathering on properties of wood-polymer composites for façade applications
Various fire-retardants (FR) for the pre-treatment of wood flour, for example, ammonium polyphosphate and different formulations based on phosphorus- and nitrogen-compounds, as well as for application during c...
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Article
Open AccessWithin-day dynamics of plant–pollinator networks are dominated by early flower closure: an experimental test of network plasticity
Temporal variability of plant–pollinator interactions is important for fully understanding the structure, function, and stability of plant–pollinator networks, but most network studies so far have ignored with...
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Article
Open AccessGlobal data on earthworm abundance, biomass, diversity and corresponding environmental properties
Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, d...
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Article
Open AccessOrally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
The COVID-19 pandemic progresses unabated in many regions of the world. An effective antiviral against SARS-CoV-2 that could be administered orally for use following high-risk exposure would be of substantial ...
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Article
Open AccessAuthor Correction: DNA damage interactions on both nanometer and micrometer scale determine overall cellular damage
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Effective therapies to treat coronavirus disease 2019 (COVID-19) are urgently needed. While many investigational, approved, and repurposed drugs have been suggested as potential treatments, preclinical data fr...
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Article
Open AccessDNA damage interactions on both nanometer and micrometer scale determine overall cellular damage
DNA double strand breaks (DSB) play a pivotal role for cellular damage, which is a hazard encountered in toxicology and radiation protection, but also exploited e.g. in eradicating tumors in radiation therapy....
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Article
Warming alters energetic structure and function but not resilience of soil food webs
Climate warming is predicted to alter the structure, stability, and functioning of food webs 1–5 . Yet, despite the importance of soil food webs for energy and nutrient turnove...
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Article
Open AccessChromatin organization revealed by nanostructure of irradiation induced γH2AX, 53BP1 and Rad51 foci
The spatial distribution of DSB repair factors γH2AX, 53BP1 and Rad51 in ionizing radiation induced foci (IRIF) in HeLa cells using super resolution STED nanoscopy after low and high linear energy transfer (LE...
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Chapter and Conference Paper
STEERING FEEL AND STEER-BY-WIRE – Design of an energy-efficient front axle for a wheel-individual steer-by-wire system illustrated by the SpeedE research vehicle
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Article
Enhancement of prestack diffraction data and attributes using a traveltime decomposition approach
Diffractions not only carry important information about small-scale subsurface structures, they also possess unique properties, which make them a powerful tool for seismic processing and imaging. Since a point...
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Article
Passive seismic source localization via common-reflection-surface attributes
The common-reflection-surface (CRS) stack can be viewed as a physically justified extension of the classical common-midpoint (CMP) stack, utilizing redundant information not only in a single, but in several ne...
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Article
Structural characterization of amphiphilic siderophores produced by a soda lake isolate, Halomonas sp. SL01, reveals cysteine-, phenylalanine- and proline-containing head groups
Soap Lake, located in Washington State, is a naturally occurring saline and alkaline lake. Several organisms inhabiting this lake have been identified as producers of siderophores that are unique in structure....
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Chapter and Conference Paper
The wheel-individually steerable front axle of the research vehicle “SpeedE” – virtual design and achieved performance of the first prototype
The Institute for Automotive Engineering at RWTH Aachen University (ika), is currently develo**, constructing, and implementing the research vehicle SpeedE as an open research and innovation platform for res...
