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  1. No Access

    Article

    Pharmacokinetic interpretation of the enterohepatic recirculation and first-pass elimination of morphine in the rat

    Morphine was administered to rats by oral, intraportal, and intravenous routes in a dose of 7.6 mg · kg −1.From the serum concentration data after intraportal administration it was calculated that the first-pass...

    Bengt E. Dahlström, Lennart K. Paalzow in Journal of Pharmacokinetics and Biopharmaceutics (1978)

  2. No Access

    Article

    Relation between morphine pharmacokinetics and analgesia

    The relationship between the multicompartmental behavior of morphine and the kinetics of the analgesic effect has been investigated using a digital computer compartment analysis program. The results obtained i.....

    Bengt E. Dahlström, Lennart K. Paalzow… in Journal of Pharmacokinetics and Biopharmac… (1978)

  3. No Access

    Article

    Pharmacokinetics of morphine in plasma and discrete areas of the rat brain

    After intravenous administration of an analgesic dose of morphine into rat, the time course of morphine concentrations was followed in plasma, whole brain, and four discrete areas of the brain during 8 hr. The.....

    Bengt E. Dahlström, Lennart K. Paalzow in Journal of Pharmacokinetics and Biopharmaceutics (1975)