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A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting

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  1. Article

    Open Access

    Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations

    Recent advancements in high-throughput genomics and targeted therapies have provided tremendous potential to identify and therapeutically target distinct mutations associated with cancers. However, to date the...

    Adam X. Miranda, Justin Kemp, Brad A. Davidson, Sara Erika Bellomo… in BMC Genomics (2024)

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  2. Article

    Open Access

    Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

    The AURORA US Metastasis Project was established with the goal to identify molecular features associated with metastasis. We assayed 55 females with metastatic breast cancer (51 primary cancers and 102 metasta...

    Susana Garcia-Recio, Toshinori Hinoue, Gregory L. Wheeler… in Nature Cancer (2023)

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