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Article
Open AccessPre-clinical validation of a pan-cancer CAR-T cell immunotherapy targeting nfP2X7
Chimeric antigen receptor (CAR)-T cell immunotherapy is a novel treatment that genetically modifies the patients’ own T cells to target and kill malignant cells. However, identification of tumour-specific anti...
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Article
Open AccessParallel recovery of chromatin accessibility and gene expression dynamics from frozen human regulatory T cells
Epigenetic features such as DNA accessibility dictate transcriptional regulation in a cell type- and cell state- specific manner, and map** this in health vs. disease in clinically relevant material is openi...