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Article
Histone H3 phosphorylation of mammalian chromosomes
Inferences about the role and location of phosphorylated histone H3 are derived primarily from biochemical studies. A few direct observations at chromosome level have shown that phosphorylation begins at the s...
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Article
Visualization of Prekinetochore Locus on the Centromeric Region of Highly Extended Chromatin Fibers: Does Kinetochore Autoantigen CENP-C Constitute a Kinetochore Organizing Center?
Kinetochore is morphologically defined as a trilaminated, highly differentiated structure at the primary constriction of mitotic chromosomes. This subcellular organella is assumed to be composed of DNA and pro...
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Article
Decondensation of pericentric heterochromatin alters the sequence of centromere separation in mouse cells
The centromeres of a genome separate in a sequential, nonrandom manner that is apparently dependent upon the quantity and quality of pericentric heterochromatin. It is becoming increasingly clear that the bio...
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Book and Conference Proceedings
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Chapter and Conference Paper
Chromosome Segregation and Aneuploidy
Of all genetic afflictions of man, aneuploidy ranks as the most prevalent. Among liveborn babies aneuploidy exist to the extent of about 0.3%, to about 5% among stillborns and a dramatic 25% among miscarriages...
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Chapter and Conference Paper
The Minor Satellite of Mouse and the Centromere
The localization of the 170 base pair alpha sequences in human and a 120 base pair minor satellite DNA sequence in mouse have generated considerable excitement about deciphering the composition of the centrome...
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Chapter
Centromere Separation: Emerging Relationship with Aneuploidy
It is well established that the centromeres of various chromosomes in a given genome at metaphase/anaphase junction separate in a species specific sequence (Vig and Rattner, 1989). In humans, for example, the ...
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Article
Sequence of centromere separation: Separation in a quasi-stable mouse-human somatic cell hybrid
A quasi-stable mouse-human hybrid cell line, HR61, containing between one and ten human chromosomes was analyzed for the sequence of centromere separation. The purpose was to determine which genome of the two ...
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Article
Sequence of centromere separation: characterization of multicentric chromosomes in a rat cell line
The B1 cell line of rat cerebral endothelium origin exhibits several dicentric and multicentric chromosomes. These chromosomes, unlike multicentrics in mouse (Vig and Zinkowski 1986) do not show premature centrom...
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Article
Sequence of centromere separation: generation of unstable multicentric chromosmes in a rat cell line
A transformed cell line, B1, of cerebral endothelial origin from the Wistar-Kyoto male rat has chromatid and chromosome type bridges in virtually every cell. It exhibits various dicentric and polycentric chromoso...
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Article
Sequence of centromere separation: differential replication of pericentric heterochromatin in multicentric chromosomes
The dicentric and multicentric chromosomes in L cells and a brain tumor cell line of mouse display only one site of kinetochore formation associated with the ‘active’ centromere. The accessory or ‘inactive’ ce...
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Article
Characterization of kinetochores in multicentric chromosomes
Long-term cultures of certain rat and mouse cell lines carry several dicentric and some multicentric chromosomes. Using antikinetochore antibodies obtainable from serum of scleroderma (var. CREST) patients we ...
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Chapter
Mutagen Testing with the Soybean Assay
The soybean (Glycine max) system tests for induction of somatic mosaicism on the leaves. This mosaicism results from genetic changes induced by the agent in question in one or more cells which are rapidly dividin...
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Chapter
Aneuploidy Induced by Agricultural Pesticides: Where Do We Stand?
Even though aneuploidy is one of the worst afflictions of man, efforts to develop a mammalian test system for the study of induced nondisjunction have largely failed. A few scattered successes usually deal wit...
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Article
Sequence of centromere separation: orderly separation of multicentric chromosomes in mouse L cells
Mouse L cells have many dicentric chromosomes and one with eight centromeres. All eight centromeres behave similarly until midmetaphase when most centromeres split into two units each in apparently quick succe...
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Article
Sequence of centromere separation: Analysis of mitotic chromosomes in man
Mitotic chromosomes from human peripheral lymphocytes studied at the junction of metaphase and anaphase show that the centromeres of various chromosomes separate in a nonrandom, apparently genetically controll...
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Chapter
Soybean System for Testing the Genetic Effects of Industrial Emissions and Liquid Effluents
The testing of complex mixtures found in today’s air, water, and soils for harmful effects on man is a gigantic and important task. This paper introduces a eukaryotic test system that yields at least qualitati...
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Article
Mutagenic effects of some anticancer antibiotics
Considering the strong correlation observed between carcinogenic and mutagenic properties of chemicals, a study of the genetic effects of antineoplastic agents is warranted in as much as these agents may ‘cure...
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Article
Sequence of centromere separation of mitotic chromosomes in Chinese hamster
Chromosome preparations in late metaphase cells from bone marrow of colcemid treated male Chinese hamsters were used to analyse the sequence of separation of sister centromeres. Chromatids of chromosomes 2 and...
