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  1. No Access

    Article

    Transfection of dendritic cells (DCs) with the CIITA gene: increase in immunostimulatory activity of DCs

    Dendritic cells (DCs) are the major antigen-presenting cells. They are able to present tumor antigens to immunologic effector cells. MHC class II molecules on DC surfaces play an important role in priming effe...

    Angela Märten, Carsten Ziske, Björn Schöttker, Silvia Weineck… in Cancer Gene Therapy (2001)

  2. No Access

    Article

    Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study

    Cytokine gene transfer into tumor cells has been shown to mediate tumor regression and antimetastatic effects in several animal models via immunomodulation. Therefore, clinical protocols have been developed to...

    Y Sun, K Jurgovsky, P Möller, S Alijagic, T Dorbic, J Georgieva, B Wittig… in Gene Therapy (1998)

  3. No Access

    Article

    Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene

    Cytokine-induced killer (CIK) cells have been shown to eradicate established tumors in a SCID mouse–human lymphoma model. CIK cells depend on exogenous addition of cytokines such as interleukin-2 (IL-2), inter...

    S Finke, B Trojaneck, P Lefterova, M Csipai, E Wagner, R Kircheis… in Gene Therapy (1998)