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  1. No Access

    Article

    Transfection of dendritic cells (DCs) with the CIITA gene: increase in immunostimulatory activity of DCs

    Dendritic cells (DCs) are the major antigen-presenting cells. They are able to present tumor antigens to immunologic effector cells. MHC class II molecules on DC surfaces play an important role in priming effe...

    Angela Märten, Carsten Ziske, Björn Schöttker, Silvia Weineck… in Cancer Gene Therapy (2001)

  2. Article

    Open Access

    Phase I clinical study applying autologous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma

    Natural killer-like T lymphocytes termed cytokine-induced killer (CIK) cells have been shown to eradicate established tumours in a severe combined immune deficient (SCID) mouse/human lymphoma model. Recently, ...

    I G H Schmidt-Wolf, S Finke, B Trojaneck, A Denkena… in British Journal of Cancer (1999)

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  3. No Access

    Article

    Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study

    Recently, cytokine gene transfer into tumour cells has been shown to mediate tumour regression in animal models via immunomodulation. Consequently, a number of clinical protocols have been developed to treat c...

    P Möller, Y Sun, T Dorbic, S Alijagic, A Makki, K Jurgovsky… in British Journal of Cancer (1998)

  4. No Access

    Article

    Vaccination with IL-12 gene-modified autologous melanoma cells: preclinical results and a first clinical phase I study

    Cytokine gene transfer into tumor cells has been shown to mediate tumor regression and antimetastatic effects in several animal models via immunomodulation. Therefore, clinical protocols have been developed to...

    Y Sun, K Jurgovsky, P Möller, S Alijagic, T Dorbic, J Georgieva, B Wittig… in Gene Therapy (1998)

  5. No Access

    Article

    Increase of proliferation rate and enhancement of antitumor cytotoxicity of expanded human CD3+CD56+ immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene

    Cytokine-induced killer (CIK) cells have been shown to eradicate established tumors in a SCID mouse–human lymphoma model. CIK cells depend on exogenous addition of cytokines such as interleukin-2 (IL-2), inter...

    S Finke, B Trojaneck, P Lefterova, M Csipai, E Wagner, R Kircheis… in Gene Therapy (1998)

  6. No Access

    Article

    Gluconeogenic-glycolytic capacities and metabolic zonation in liver of rats with streptozotocin, non-ketotic as compared to alloxan, ketotic diabetes

    Activities (μmol x min−1 x g liver) and zonal distributions of key enzymes of carbohydrate metabolism were studied in livers of streptozotocin-diabetic rats and compared to the values in alloxan-diabetes.

      H. Miethke, B. Wittig, A. Nath, K. Jungermann in Histochemistry (1986)