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Article
Open AccessCaspase-2 impacts lung tumorigenesis and chemotherapy response in vivo
Caspase-2 is an atypical caspase that regulates apoptosis, cell cycle arrest and genome maintenance, although the mechanisms are not well understood. Caspase-2 has also been implicated in chemotherapy response...
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Chapter and Conference Paper
High-dose Therapy and Autografting with Mobilized Peripheral Blood Progenitor Cells in Patients with Malignant Lymphoma
In this report we present the data of 100 patients who were autografted with peripheral blood progenitor cells (PBPC) following high-dose conditioning therapy. Fifty-six patients were male and 44 were female w...
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Article
Detection of minimal tumor load in blood stem cell autografts in multiple myeloma: Steady-state versus high-dose chemotherapy stem cell mobilization
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Chapter and Conference Paper
Autologous Transplantation with Mafosfamide-Purged Bone Marrow for Acute Myelogenous Leukemia in First and Second Complete Remission
Despite improvements in the conventional treatment of adult patients with acute myelogenous leukemia (AML) the probability of Gontinuous CR ranges from 8% to 45% at 3 years [1]. Intensive consolidation therapy...
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Chapter and Conference Paper
Idarubicin/Cytosine Arabinoside and Mitoxantrone/Etoposide with rhGM-CSF Priming for De Novo Acute Myelogenous Leukemia
With conventional induction chemotherapy 60 to 70% of adult patients with acute myelogenous leukemia (AML) achieve complete remission (CR) [1]. Chemotherapeutic protocols for induction treatment mainly consist...
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Chapter
Mobilization of Blood Stem Cells with Recombinant Human (rh)G-CSF in Patients with Hematological Malignancies and Solid Tumors
Peripheral blood stem cells (PBSC) are being increasingly used for autografting in patients with malignant diseases to circumvent the myelotoxic effects of high-dose therapy [1]. It is generally accepted that ...
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Chapter and Conference Paper
Autologous Bone Marrow Transplantation in Patients with Acute Lymphoblastic Leukemia in Second or Subsequent Complete Remission
With intensive conventional chemotherapy a complete remission (CR) can be achieved in more than 90% of children and 70% of adults with ALL [l].The long-term disease-free survival for patients with ALL depends ...
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Chapter and Conference Paper
Autologous Transplantation of Blood Stem Cells Mobilized with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor Subsequent to Chemotherapy for Relapsed Hodgkin’s Disease
High-dose chemotherapy alone or combined with total body irradiation followed by autologous bone marrow transplantation improves disease-free survival for patients with hematological malignancies and solid tum...
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Chapter and Conference Paper
Induction Therapy for Acute Myelogenous Leukemia with Idarubicin/Cytosine Arabinoside and Mitoxantrone/Etoposide in “Response-Adapted” Sequence
With conventional induction chemotherapy 47%–72% of adult patients with acute myelogenous leukemia (AML) achieve complete remission (CR). However, the probability of continuous CR ranges from 8% to 45% at 3 ye...
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Article
Abstract