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  1. No Access

    Reference Work Entry In depth

    In Vivo Imaging of Neurotransmitter Systems with PET

    The advent of functional neuroimaging techniques has significantly widened the methodological repertoire of neurochemistry. Using positron emission tomography PET, the human and non-human primate brain's neuro...

    B. Gulyás, C. Halldin, B. Mazière in Handbook of Neurochemistry and Molecular Neurobiology (2008)

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    Article

    Iodine-123 labelled radiopharmaceuticals and single-photon emission tomography: A natural liaison

    Most nuclear medicine departments possess one or more imaging apparatuses for single-photon emission tomography (SPET). Molecules of biological interest to assess metabolism and receptor function are often lab...

    M. H. Bourguignon, E. K. J. Pauwels, C. Loc'h… in European Journal of Nuclear Medicine (1997)

  3. No Access

    Chapter

    Interaction of Lisuride with dopaminergic receptors

    The dopaminergic system was the first neurotransmission system in which it was possible to image receptors, neurotransmitter and neurotransmitter reuptake systems.

    B. Mazière, R. Horowski in PET for Drug Development and Evaluation (1995)

  4. No Access

    Chapter

    Contribution of Positron Emission Tomography to Pharmacokinetic Studies

    Pharmacokinetics, whose aim is to explain and predict drug action in the human body, describes the processes that determine the concentration of the active substance at its site of action.

    B. Mazière, J. Delforge in Pharmacokinetics of Drugs (1994)

  5. No Access

    Chapter

    Preclinical Data Necessary to Assess PET Examinations

    PET allows in humans the monitoring of the time-course of regional tissue tracer concentration after administration of a positron emitting radiopharmaceutical. When the radiopharmaceutical is a substrate for a...

    B. Mazière, C. Loc’h, M. Mazière in Progress in Radiopharmacy (1992)

  6. No Access

    Chapter

    Contribution of Positron Emission Tomography to Pharmacokinetic Studies

    Positron Emission Tomography (PET) is a safe non-invasive visualization technique that provides serial quantitative images of the spatial distribution of a previously administered molecule labelled with a posi...

    B. Mazière, M. Mazière, J. Delforge, A. Syrota in New Trends in Pharmacokinetics (1991)

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    Article

    Where have we got to with neuroreceptor map** of the human brain?

    In the past two decades, tritiated radioligand receptor binding, a tool commonly used to investigate the site of action of drugs in laboratory animals, has provided a vast body of information on neuropharmacol...

    B. Mazière, M. Mazière in European Journal of Nuclear Medicine (1990)

  8. No Access

    Chapter and Conference Paper

    PET Imaging of D2 Receptors in the Living Baboon and Human Brain in Normal and Pathological Conditions Using [76Br]Bromolisuride

    In the early 1970s, brain imaging was revolutionized by the combination of computer and external detection systems for electromagnetic waves resulting in three-dimensional imaging techniques such as magnetic r...

    B. Mazière, C. Loch, P. Hantraye, O. Stulzaft, J. L. Martinot… in Neuropsychopharmacology (1990)

  9. No Access

    Chapter

    Progressive Supranuclear Palsy Studied by Pet

    Among the movement disorders progressive supranuclear palsy (PSP) is a degenerative neurological disease characterized by a loss of voluntary control of vertical gaze, dysarthria, diffuse body rigidity with dy...

    B. Mazière, J. C. Baron, C. Loc’h, H. Cambon… in Clinical efficacy of positron emission tom… (1987)

  10. No Access

    Article

    Simple, fast preparation of gallium-68-labelled human serum albumin microspheres

    Following a study of the main factors involved in the 68-Ga labelling of human serum albumin microspheres (H.S.A.M.), especially methods of production and preparation of active solution and conditions of radio...

    J. P. Yvert, B. Mazière, M. Verhas, D. Comar in European Journal of Nuclear Medicine (1979)

  11. No Access

    Article

    Application of neutron activation analysis to the study of the variations of the concentration of trace elements in various organs of rat as a function of age

    In order to know the normal distribution of trace elements is rats, in terms of age, we have determined the elemental composition of different organs and body tissues by neutron activation analysis following a...

    B. Mazière, C. Loc’h, O. Stulzaft, A. Gaudry… in Journal of Radioanalytical Chemistry (1977)