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Chapter
Acetylcholine Turnover in Mouse Brain: Influence of Cholinesterase Inhibitors
Evidence has been presented to indicate that in neurons the concentrations of neurotransmitters are maintained at constant levels although the rates of transmitter metabolism are changing (10, 13). However, in...
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Article
Pharmacokinetics of terodiline in human volunteers
The pharmacokinetics of terodiline HCl was studied in nine healthy volunteers given 12.5 mg i.v. and p.o. or 20 mg i.v. and 25 mg p.o. on two different occasions. The serum concentrations were measured by gas ...
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Article
Absorption of boron after mouthwash treatment with Bocosept
Healthy volunteers and patients with gingivitis were treated locally with the boron-containing bacteriostatic agent, Bocosept. Blood levels and urinary excretion of boron were examined by a spectrophotometric ...
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Article
Assay of the major (4-hydroxylated) metabolites of diphenylhydantoin in human urine
A modified gas chromatographic procedure for the determination of unconjugated and conjugated 4-hydroxydiphenylhydantoin (4-OH-DPH) in urine has been developed.
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Article
N-(t-Aminoalkynyl)-substituted pyrrolidones as oxotremorine antagonists
Eine Anzahl von Antagonisten zu Oxotremorin wurden durch kleine Modifikationen der Struktur des Oxotremorins erhalten. Die aktivste Verbindung, N-(1-Methyl-4-pyrrolidino-2-butinyl)pyrrolidon, ist mehr als sech...
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Article
Identification of Acetylcholine in Fresh Rat Brain by Combined Gas Chromatography–Mass Spectrometry
ACETYLCHOLINE was first identified in animal tissue by Dale and Dudley1. They isolated acetylcholine as the double choline–acetylcholine dichloroplatinate from 40 kg of horse spleen. Its identity was demonstrated...