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  1. No Access

    Chapter

    Acetylcholine Turnover in Mouse Brain: Influence of Cholinesterase Inhibitors

    Evidence has been presented to indicate that in neurons the concentrations of neurotransmitters are maintained at constant levels although the rates of transmitter metabolism are changing (10, 13). However, in...

    B. Karlén, G. Lundgren, J. Lundin, B. Holmstedt in Dynamics of Cholinergic Function (1986)

  2. No Access

    Article

    Pharmacokinetics of terodiline in human volunteers

    The pharmacokinetics of terodiline HCl was studied in nine healthy volunteers given 12.5 mg i.v. and p.o. or 20 mg i.v. and 25 mg p.o. on two different occasions. The serum concentrations were measured by gas ...

    B. Karlén, K. -E. Andersson, G. Ekman… in European Journal of Clinical Pharmacology (1982)

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    Article

    Absorption of boron after mouthwash treatment with Bocosept

    Healthy volunteers and patients with gingivitis were treated locally with the boron-containing bacteriostatic agent, Bocosept. Blood levels and urinary excretion of boron were examined by a spectrophotometric ...

    L. Edwall, B. Karlén, A. Rosén in European Journal of Clinical Pharmacology (1979)

  4. No Access

    Article

    Assay of the major (4-hydroxylated) metabolites of diphenylhydantoin in human urine

    A modified gas chromatographic procedure for the determination of unconjugated and conjugated 4-hydroxydiphenylhydantoin (4-OH-DPH) in urine has been developed.

    B. Karlén, M. Garle, A. Rane, Marcela Gutova… in European Journal of Clinical Pharmacology (1975)

  5. No Access

    Article

    N-(t-Aminoalkynyl)-substituted pyrrolidones as oxotremorine antagonists

    Eine Anzahl von Antagonisten zu Oxotremorin wurden durch kleine Modifikationen der Struktur des Oxotremorins erhalten. Die aktivste Verbindung, N-(1-Methyl-4-pyrrolidino-2-butinyl)pyrrolidon, ist mehr als sech...

    S. Lindgren, Å. Lindquist, B. Lindeke, U. Svensson, B. Karlén, R. Dahlbom… in Experientia (1970)

  6. No Access

    Article

    Identification of Acetylcholine in Fresh Rat Brain by Combined Gas Chromatography–Mass Spectrometry

    ACETYLCHOLINE was first identified in animal tissue by Dale and Dudley1. They isolated acetylcholine as the double choline–acetylcholine dichloroplatinate from 40 kg of horse spleen. Its identity was demonstrated...

    C.-G. HAMMAR, I. HANIN, B. HOLMSTEDT, R. J. KITZ, D. J. JENDEN, B. KARLÉN in Nature (1968)