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  1. No Access

    Article

    Patients with Down syndrome can be included in early phase clinical trials- a report from the T2016-003 Therapeutic Advances in Childhood Leukemia and Lymphoma (TACL) study

    N. Gossai, D. Bhojwani, E. S. Schafer, B. H. Chang, L. Pommert, A. Verma… in Leukemia (2023)

  2. No Access

    Article

    Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes

    We recently demonstrated that acute myeloid leukemia (AML) cell lines and patient-derived blasts release exosomes that carry RNA and protein; following an in vitro transfer, AML exosomes produce proangiogenic cha...

    J Huan, N I Hornick, N A Goloviznina, A N Kamimae- Lanning, L L David… in Leukemia (2015)

  3. Article

    Open Access

    Targeting survivin and p53 in pediatric acute lymphoblastic leukemia

    Despite advances in treatment and outcomes for patients with pediatric acute lymphoblastic leukemia (ALL), there continue to be subsets of patients who are refractory to standard chemotherapy and hematopoietic...

    J W Tyner, A M Jemal, M Thayer, B J Druker, B H Chang in Leukemia (2012)

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  4. No Access

    Article

    Chromosomes with delayed replication timing lead to checkpoint activation, delayed recruitment of Aurora B and chromosome instability

    Certain chromosome rearrangements display a significant delay in chromosome replication timing (DRT) that is associated with a subsequent delay in mitotic chromosome condensation (DMC). DRT/DMC chromosomes are co...

    B H Chang, L Smith, J Huang, M Thayer in Oncogene (2007)