11 Result(s)

Article

DIABETES MELLITUS AND VASCULAR DISEASE: POSSIBLE ROLE OF HYDROXYACIDS IN ITS GENESIS

Studies to date have not elucidated the cause(s) for diabetic neovascular proliferation. We report that a metabolite of arachidonic acid (AA), 15 hydroxyeicosatetraenoic acid (15HETE) is present in vessels, pl...

M Stuart, J Graeber, Y Setty, R Walenga, T Conner, B Glaser in Pediatric Research (1984)

Article

Radiation therapy and treatment results of malignant tumors of the nasal cave

B. Glaser, L. Schertel, H. D. Böttcher… in Journal of Cancer Research and Clinical On… (1986)

Article

14 PERSISTENT HYPERINSULINENIC HYPOGLYCEMIA OF INFANCY – LONG-TERM EXPERIENCE WITH 28 PATIENTS

We studied 28 patients with Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI). Twenty-two developed symptomatic hypoglycemia within 2 days of life (15 of these required surgery) while 5 developed firs...

H Landau, B Glaser, H J Hirsch, M Schiller, V Gross, A Corcos… in Pediatric Research (1988)

Article

Regulation of insulin release in persistent hyperinsulinaemic hypoglycaemia of infancy studied in long-term culture of pancreatic tissue

Pancreatic tissue was obtained during therapeutic subtotal pancreatectomy from five infants with persistent hyperinsulinaemic hypoglycaemia of infancy (so-called nesidioblastosis). Collagenase digests of the s...

N. Kaiser, A. P. Corcos, A. Tur-Sinai, Y. Ariav, B. Glaser, H. Landau… in Diabetologia (1990)

Article

Normal proinsulin processing despite beta-cell dysfunction in persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis)

Persistent hyperinsulinaemic hypoglycaemia of infancy (PHHI) is a genetic disorder which causes severe hypoglycaemia in the neonate. The beta cells fail to respond to changes in blood glucose levels in all th...

G. Leibowitz, N. Weintrob, A. Pikarsky, Z. Josefsberg, H. Landau, B. Glaser… in Diabetologia (1996)

Article

Map** of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role

Insulin receptor substrate 2 (IRS-2) is a substrate of the insulin receptor and mediates the action of the insulin. Disruption of the IRS-2 gene in mice results in peripheral insulin resistance and relative i...

K. Kalidas, J. Wasson, B. Glaser, J. M. Meyer, L. J. Duprat, M. F. White… in Diabetologia (1998)

Article

Isolation and characterization of the human AKT1 gene, identification of 13 single nucleotide polymorphisms (SNPs), and their lack of association with Type II diabetes

Aims/hypothesis. AKT1, a serine/threonine protein kinase, is an important downstream target of the insulin-signalling pathway, with both anti-apoptotic and peripheral metabolic effects. Because i...

A. Matsubara, J. C. Wasson, S. S. Donelan, C. M. Welling, B. Glaser… in Diabetologia (2001)

Article

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation

Recently, variants in WFS1 have been shown to be associated with type 2 diabetes. We aimed to examine metabolic risk phenotypes of WFS1 variants in glucose-tolerant people and in individuals with abnormal glucose...

T. Sparsø, G. Andersen, A. Albrechtsen, T. Jørgensen, K. Borch-Johnsen… in Diabetologia (2008)