![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Map** the gene encoding the human erythroid transcriptional factor NFE1-GF1 to Xp11.23
The X-linked NFE1 gene encodes an erythroid factor involved in globin gene transcription. Using a human cDNA clone encoding this factor, we show, by in situ hybridization and by analysis of human-rodent hybrid...
-
Article
A frequent Aγ-persistence of fetal hemoglobin in northern Sardinia: its molecular basis and hematologic phenotype in heterozygotes and compound heterozygotes with β-thalassemia
A survey of hemoglobinopathies in northern Sardinia revealed a high frequency (0.3%) of carriers of a hematologic condition characterized by increased expression of fetal hemoglobin during adult life (heredita...
-
Article
Globin gene deletion in HPFH, δ°β° thalassaemia and Hb Lepore disease
THE thalassaemias are a group of inherited disorders characterised by the defective production of either α (α thalassaemias) or non-α (β and δ°β° thalassaemias) globin chains of haemoglobins (Hb)1. In β thalassae...
-
Article
Globin RNA sequences in human leukaemic peripheral blood
EVIDENCE for the involvement of more than one cell line and even interconversion of different forms of human leukaemia suggests that the neoplastic transformation occurs in a common stem cell1. Although erythroid...
-
Article
β-Globin mRNA in Ferrara β0-thalassaemia (reply)
-
Article
Direct demonstration of β-globin mRNA in homozygous Ferrara β0-thalassaemia patients
In cases of β0- thalassaemia from Ferrara, Italy, the β-globin gene is transcribed into mRNA but no protein is synthesised. For these cases there is no hybridisation data suggesting a globin gene structural mutat...