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  1. Article

    Open Access

    Acute myocardial infarction does not affect functional characteristics of adipose-derived stem cells in rats, but reduces the number of stem cells in adipose tissue

    In most pre-clinical animal studies investigating stem cell therapy in acute myocardial infarction (AMI), the administered stem cells are isolated from healthy donors. In clinical practice, however, patients w...

    B. A. Naaijkens, P. A. J. Krijnen, E. Meinster, E. N. ter Horst… in Cell and Tissue Research (2015)

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    Article

    Therapeutic Application of Adipose Derived Stem Cells in Acute Myocardial Infarction: Lessons from Animal Models

    The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, ...

    B. A. Naaijkens, A. van Dijk, O. Kamp, P. A. J. Krijnen… in Stem Cell Reviews and Reports (2014)

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    Article

    The multidrug resistance protein breast cancer resistance protein (BCRP) protects adipose-derived stem cells against ischemic damage

    Adipose tissue-derived stem cells (ASCs) are promising candidates for regenerative therapy, like after myocardial infarction. However, when transplanted into the infarcted heart, ASCs are jeopardized by the is...

    A. van Dijk, B. A. Naaijkens, W. J. F. M. Jurgens… in Cell Biology and Toxicology (2012)

  4. Article

    Open Access

    Human platelet lysate as a fetal bovine serum substitute improves human adipose-derived stromal cell culture for future cardiac repair applications

    Adipose-derived stromal cells (ASC) are promising candidates for cell therapy, for example to treat myocardial infarction. Commonly, fetal bovine serum (FBS) is used in ASC culturing. However, FBS has several ...

    B. A. Naaijkens, H. W. M. Niessen, H-J. Prins, P. A. J. Krijnen… in Cell and Tissue Research (2012)

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