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  1. Article

    Open Access

    Tyrosine kinase inhibition increases the cell surface localization of FLT3-ITD and enhances FLT3-directed immunotherapy of acute myeloid leukemia

    The fms-related tyrosine kinase 3 (FLT3) receptor has been extensively studied over the past two decades with regard to oncogenic alterations that do not only serve as prognostic markers but also as therapeuti...

    K Reiter, H Polzer, C Krupka, A Maiser, B Vick, M Rothenberg-Thurley… in Leukemia (2018)

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  2. No Access

    Article

    Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism

    Bispecific T-cell engagers (BiTEs) are very effective in recruiting and activating T cells. We tested the cytotoxicity of the CD33/CD3 BiTE antibody construct AMG 330 on primary acute myeloid leukemia (AML) ce...

    C Krupka, P Kufer, R Kischel, G Zugmaier, F S Lichtenegger, T Köhnke, B Vick… in Leukemia (2016)

  3. No Access

    Chapter

    Computational Aspects of the Boundary Element Method Applied to Frictional Heating

    A variation of the boundary element method is developed to solve for the distribution of frictional heat and ensuing temperature rise caused by frictional heating between sliding solids. The problem under cons...

    B. Vick, L. P. Golan II in Boundary Elements XIII (1991)