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Article
Essential role for Bclaf1 in lung development and immune system function
Bcl-2 associated factor 1 (Bclaf1) is a nuclear protein that was originally identified in a screen of proteins that interact with the adenoviral bcl-2 homolog E1B19K. Overexpression of Bclaf1 was shown to resu...
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Article
Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells
Previously, we analyzed mice lacking either caspase-2 or caspase-3 and documented a role for caspase-2 in developmental and chemotherapy-induced apoptosis of oocytes. Those data also revealed dispensability of...
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Article
Fine characterization of childhood and adult acute lymphoblastic leukemia (ALL) by a proB and preB surrogate light chain-specific mAb and a proposal for a new B cell ALL classification
The expression of the surrogate light chain (ΨL) – made of the λ-like (or λ5) and the VpreB proteins – is a B cell-specific maturation marker. Using an anti-human VpreB mAb (4G7), we recently identified in hum...