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Cerium oxide nanoparticles protect against Aβ-induced mitochondrial fragmentation and neuronal cell death
Evidence indicates that nitrosative stress and mitochondrial dysfunction participate in the pathogenesis of Alzheimer’s disease (AD). Amyloid beta (Aβ) and peroxynitrite induce mitochondrial fragmentation and neu...
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Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity
Optic atrophy 1 ( OPA1 ) mutations cause dominant optic atrophy (DOA) with retinal ganglion cell (RGC) and optic nerve degeneration. The mechanism for the selectiv...
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Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway
Mitochondrial respiratory complex II inhibition plays a central role in Huntington's disease (HD). Remarkably, 3-NP, a complex II inhibitor, recapitulates HD-like symptoms. Furthermore, decreases in mitochondr...