3,084 Result(s)
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Geriatrics/Gerontology
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Article
Open AccessAssociations of plasma proteomics and age-related outcomes with brain age in a diverse cohort
Machine learning models are increasingly being used to estimate “brain age” from neuroimaging data. The gap between chronological age and the estimated brain age gap (BAG) is potentially a measure of accelerat...
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RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Polyalthia longifolia is well-known for its abundance of polyphenol content and traditional medicinal uses. Previous research has demonstrated that the methanolic extract of P. longifolia leaves (PLME, 1 mg/mL) p...
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DNA methylation-based estimators of telomere length show low correspondence with paternal age at conception and other measures of external validity of telomere length
In humans, DNA methylation (DNAm) based estimators of telomere length (TL) have been shown to better predict TL-associated variables (e.g., age, sex, and mortality) than TL itself. The biological significance ...
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Correction to: Lifespan effects in male UM‑HET3 mice treated with sodium thiosulfate, 16‑hydroxyestriol, and late‑start canagliflozin
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Open AccessNo Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults
This study aimed to investigate the relationship between childhood adversity and cognitive impairment in older adults.
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Open AccessLower Incidence of Dementia Following Cancer Diagnoses: Evidence from a Large Cohort and Mendelian Randomization Study
The reported inverse association between cancer and subsequent Alzheimer’s disease and related dementias (ADRD) remains uncertain.
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Open AccessAssociation between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study
Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty Index (FI) definition to (1) investigate the association between...
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On the 2024 Alzheimer’s Association Criteria: Still Not Ready for Clinical Use
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Open AccessInstruments for measuring the neuromuscular function domain of vitality capacity in older persons: an umbrella review
This umbrella review aimed to identify the available assessments to measure neuromuscular function in community-dwelling older adults, and to critically review their measurement properties.
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Open AccessCorrection: Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid angiopathy
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Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
With devastating health and socioeconomic impact worldwide, much work is left to understand the Coronavirus Disease 2019 (COVID-19), with emphasis in the severely affected elderly population. Here, we present ...
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Open AccessAssociation of physical function with connectivity in the sensorimotor and dorsal attention networks: why examining specific components of physical function matters
Declining physical function with aging is associated with structural and functional brain network organization. Gaining a greater understanding of network associations may be useful for targeting interventions...
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Open AccessImplementation and evaluation of a community-based mindful walking randomized controlled trial to sustain cognitive health in older African Americans at risk for dementia
With an increasing proportion of older adults and the associated risk of Alzheimer’s Disease and Related Dementias (ADRD) around the globe, there is an urgent need to engage in ADRD risk reduction efforts. Afr...
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Open AccessThe performance of metabolomics-based prediction scores for mortality in older patients with solid tumors
Prognostic information is needed to balance benefits and risks of cancer treatment in older patients. Metabolomics-based scores were previously developed to predict 5- and 10-year mortality (MetaboHealth) and ...
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The Causal Relationship between Genetically Predicted Biological Aging, Alzheimer’s Disease and Cognitive Function: A Mendelian Randomisation Study
Aging is one of the most important risk factors for Alzheimer’s disease (AD). Biological aging is a better indicator of the body’s functional state than age (chronological aging). Leukocyte telomere length (LT...
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Konservative Frakturversorgung bei alten Menschen
Die demografische Entwicklung wird zur deutlichen Zunahme osteoporotischer Frakturen führen, diese betreffen insbesondere das proximale Femur, das Becken, den proximalen Humerus, das Handgelenk und die Wirbelk...
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Rehabilitationsbedarf geriatrischer Patienten in Kurzzeitpflege nach akutstationärem Aufenthalt – ein vernachlässigter Versorgungsanspruch
Geriatrische Patienten nehmen nach akutstationärer Behandlung häufig Kurzzeitpflege (KZP) in Anspruch. Über deren Versorgung und die Entwicklung ihres Gesundheitsstatus ist bisher wenig bekannt.
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Self-Reported Fatigue and Its Cross-Sectional Associations with Physical Function throughout Adulthood: The INSPIRE-T Cohort
Fatigue negatively impacts health outcomes but its association with physical function across the adulthood remains unclear.
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Open AccessPerceived but not objective measures of neighborhood safety and food environments are associated with longitudinal changes in processing speed among urban older adults
Although a growing body of literature documents the importance of neighborhood effects on late-life cognition, little is known about the relative strength of objective and subjective neighborhood measures on l...
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Open AccessAge, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients
Aging and sex are major risk factors for develo** late-onset Alzheimer’s disease. Compared to men, women experience worse neuropathological burden and cognitive decline despite living longer with the disease...
