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  1. Article

    Open Access

    Sodium glucose cotransporter 2 inhibitor suppresses renal injury in rats with renal congestion

    Renal congestion is an issue of cardiorenal syndrome in patients with heart failure. Recent clinical and basic studies suggest a renoprotective potential of sodium–glucose cotransporter (SGLT) 2 inhibitors. Ho...

    Akari Endo, Takuo Hirose, Shigemitsu Sato, Hiroki Ito in Hypertension Research (2024)

  2. Article

    Open Access

    Pericyte detachment and renal congestion involve interstitial injury and fibrosis in Dahl salt-sensitive rats and humans with heart failure

    Congestive heart failure produces fluid volume overload, central and renal venous pressure elevation, and consequently renal congestion, which results in worsening renal function. Pericyte detachment and peric...

    Hiroki Ito, Takuo Hirose, Shigemitsu Sato, Chika Takahashi in Hypertension Research (2023)

  3. No Access

    Article

    MPO-ANCA-positive conversion and microscopic polyangiitis development in idiopathic interstitial pneumonia: a case report

    Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a systemic autoimmune disease characterized by necrotizing inflammation of the small blood vessels. ANCA-associated vasculitis is subclassifi...

    Shingo Nakayama, Akari Endo, Takuo Hirose, Keiji Matsumoto in CEN Case Reports (2023)

  4. Article

    Open Access

    Controlled self-assembly of plant proteins into high-performance multifunctional nanostructured films

    The abundance of plant-derived proteins, as well as their biodegradability and low environmental impact make them attractive polymeric feedstocks for next-generation functional materials to replace current pet...

    Ayaka Kamada, Marc Rodriguez-Garcia, Francesco Simone Ruggeri in Nature Communications (2021)

  5. No Access

    Article

    Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition

    Membrane-less organelles resulting from liquid–liquid phase separation of biopolymers into intracellular condensates control essential biological functions, including messenger RNA processing, cell signalling ...

    Yi Shen, Francesco Simone Ruggeri, Daniele Vigolo, Ayaka Kamada in Nature Nanotechnology (2020)