19 Result(s)

Article

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

Fecal microbiota transplantation (FMT) and fecal virome transplantation (FVT, sterile filtrated donor feces) have been effective in treating recurrent Clostridioides difficile infections, possibly through bacteri...

Torben Sølbeck Rasmussen, **aotian Mao, Sarah Forster, Sabina Birgitte Larsen… in Microbiome (2024)

Article

Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice

Metabolic syndrome encompasses amongst other conditions like obesity and type-2 diabetes and is associated with gut microbiome (GM) dysbiosis. Fecal microbiota transplantation (FMT) has been explored to treat ...

**aotian Mao, Sabina Birgitte Larsen… in Nature Communications (2024)

Article

Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model

Gut microbiota dysbiosis is associated with the development of non-alcoholic steatohepatitis (NASH) through modulation of gut barrier, inflammation, lipid metabolism, bile acid signaling and short-chain fatty ...

Ditte Olsen Lützhøft, Tim Sinioja, Berit Ø. Christoffersen… in BMC Microbiology (2022)

Article

Controlling the uncontrolled variation in the diet induced obese mouse by microbiomic characterization

Group sizes in an animal study are calculated from estimates on variation, effect, power and significance level. Much of the variation in glucose related parameters of the diet-induced obese (DIO) mouse model ...

Valeriia Bondarenko, Cecillie Reynolds Løkke, Peter Dobrowolski… in Scientific Reports (2022)

Article

Oligosaccharide equine feed supplement, Immulix, has minor impact on vaccine responses in mice

Several mammalian species are vaccinated in early life, but little is known about the effect of diet on vaccine response. Oligosaccharides are increasingly proposed as dietary supplement for young individuals ...

Ida Wang Henriksen, Josue Leonardo Castro Mejia… in Scientific Reports (2022)

Article

The microbiome and rodent models of immune mediated diseases

Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with litt...

Axel Kornerup Hansen, Camilla Hartmann Friis Hansen in Mammalian Genome (2021)

Article

Systems-wide effects of short-term feed deprivation in obese mice

While prolonged fasting induces significant metabolic changes in humans and mice, less is known about systems-wide metabolic changes in response to short-term feed deprivation, which is used in experimental an...

Daniel Andersen, Henrik Munch Roager, Li Zhang, Janne Marie Moll… in Scientific Reports (2021)

Article

C57BL/6J substrain differences in response to high-fat diet intervention

C57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift and environmental confounders s...

Majken Storm Siersbæk, Nicholas Ditzel, Eva Kildall Hejbøl… in Scientific Reports (2020)

Article

Long-term Western diet fed apolipoprotein E-deficient rats exhibit only modest early atherosclerotic characteristics

In the apolipoprotein E–deficient mouse, the gut microbiota has an impact on the development of atherosclerosis, but whether such correlations are also present in rats requires investigation. Therefore, we stu...

Ida Rune, Bidda Rolin, Jens Lykkesfeldt, Dennis Sandris Nielsen… in Scientific Reports (2018)

Article

Effects of Gliadin consumption on the Intestinal Microbiota and Metabolic Homeostasis in Mice Fed a High-fat Diet

Dietary gluten causes severe disorders like celiac disease in gluten-intolerant humans. However, currently understanding of its impact in tolerant individuals is limited. Our objective was to test whether glia...

Li Zhang, Daniel Andersen, Henrik Munch Roager, Martin Iain Bahl… in Scientific Reports (2017)

Article

Sensitivity to oxazolone induced dermatitis is transferable with gut microbiota in mice

Atopic Dermatitis (AD) has been associated with gut microbiota (GM) dysbiosis in humans, indicating a causative role of GM in AD etiology. Furthermore, the GM strongly correlates to essential disease parameter...

Line Fisker Zachariassen, Lukasz Krych, Kåre Engkilde… in Scientific Reports (2017)

Article

Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass in piglets

Surgery under cardiopulmonary bypass (CPB) is still associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully understood. Abnormalities in coron...

Petru Liuba, Sune Johansson, Erkki Pesonen… in Journal of Cardiothoracic Surgery (2013)

Article

Rearing and Caring for a Future Xenograft Donor Pig

Axel Kornerup Hansen, Kirsten Dahl, Dorte Bratbo Sørensen in Acta Veterinaria Scandinavica (2004)

Article

Xenotransplantation – State of the Art

Axel Kornerup Hansen, Kirsten Dahl, Dorte Bratbo Sørensen… in Acta Veterinaria Scandinavica (2004)