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Open AccessClonal evolution and blastic plasmacytoid dendritic cell neoplasm: malignancies of divergent hematopoietic lineages emerging from a common founding clone
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Open AccessGenome-wide DNA methylation-analysis of blastic plasmacytoid dendritic cell neoplasm identifies distinct molecular features
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) constitutes a rare and aggressive malignancy originating from plasmacytoid dendritic cells (pDCs) with a primarily cutaneous tropism followed by disseminati...
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Article
Open AccessDiagnostic management of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in close interaction with therapeutic considerations
Blastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare malignancy derived from plasmacytoid dendritic cells, can mimic both acute leukemia and aggressive T-cell lymphoma. Therapy of this highly aggressiv...
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Article
Open AccessA comprehensive analysis of gut and skin microbiota in canine atopic dermatitis in Shiba Inu dogs
Like its human counterpart, canine atopic dermatitis (cAD) is a chronic relapsing condition; thus, most cAD-affected dogs will require lifelong treatment to maintain an acceptable quality of life. A potential ...
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Article
Open AccessUncovering the relationship between gut microbial dysbiosis, metabolomics, and dietary intake in type 2 diabetes mellitus and in healthy volunteers: a multi-omics analysis
Type 2 Diabetes Mellitus has reached epidemic levels globally, and several studies have confirmed a link between gut microbial dysbiosis and aberrant glucose homeostasis among people with diabetes. While the a...
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Open AccessMolecularly Stratified Treatment Options in Primary Refractory DLBCL/HGBL with MYC and BCL2 or BCL6 Rearrangements (HGBL, NOS with MYC/BCL6)
There is growing evidence supporting multidisciplinary molecular tumor boards (MTB) in solid tumors whereas hematologic malignancies remain underrepresented in this regard.
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Article
Open AccessMBECS: Microbiome Batch Effects Correction Suite
Despite the availability of batch effect correcting algorithms (BECA), no comprehensive tool that combines batch correction and evaluation of the results exists for microbiome datasets. This work outlines the ...
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Article
Open AccessPanomics reveals patient individuality as the major driver of colorectal cancer progression
Colorectal cancer (CRC) is one of the most prevalent cancers, with over one million new cases per year. Overall, prognosis of CRC largely depends on the disease stage and metastatic status. As precision oncolo...
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Open AccessIntegrative molecular profiling identifies two molecularly and clinically distinct subtypes of blastic plasmacytoid dendritic cell neoplasm
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Article
Open AccessBiodiversity of mycobial communities in health and onychomycosis
Onychomycosis (OM) is a common fungal nail infection. Based on the rich mycobial diversity in healthy toenails, we speculated that this is lost in OM due to the predominance of a single pathogen. We used next ...
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Article
Open AccessPerformance of international prognostic indices in plasmablastic lymphoma: a comparative evaluation
Plasmablastic lymphoma (PBL) is a rare and aggressive B-cell malignancy with a heterogenous clinical and prognostic spectrum, determined by multiple factors, including age, HIV- and MYC-status. While there exist ...
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Article
Open AccessGenomic insights into the pathogenesis of Epstein–Barr virus-associated diffuse large B-cell lymphoma by whole-genome and targeted amplicon sequencing
Epstein–Barr virus (EBV)-associated diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS) constitute a distinct clinicopathological entity in the current World Health Organization (WHO) classificat...
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Article
Open AccessAn integrated personal and population-based Egyptian genome reference
A small number of de novo assembled human genomes have been reported to date, and few have been complemented with population-based genetic variation, which is particularly important for North Africa, a region ...
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Article
Open AccessLow-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes...
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Analytic Methods in Microbiome Studies
Most autoimmune diseases are polygenic conditions, with strong environmental components. For example, rheumatoid arthritis (RA) has approximately 100 risk alleles, with small individual effect sizes, indicatin...
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Open AccessMitochondrial gene polymorphism is associated with gut microbial communities in mice
Gut microbial communities are key mediators of health and disease and have the capacity to drive the pathogenesis of diverse complex diseases including metabolic and chronic inflammatory diseases as well as ag...
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Open AccessTranscriptome assemblies for studying sex-biased gene expression in the guppy, Poecilia reticulata
Sexually dimorphic phenotypes are generally associated with differential gene expression between the sexes. The study of molecular evolution and genomic location of these differentially expressed, or sex-biase...
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Article
Open AccessThe genomic landscape of species divergence in Ficedula flycatchers
The results of sequencing the collared flycatcher genome, and re-sequencing population samples from this species and its sister species, the pied flycatcher, reveal the existence of areas of high sequence dive...
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Article
Open AccessMolecular evolution of genes in avian genomes
Obtaining a draft genome sequence of the zebra finch (Taeniopygia guttata), the second bird genome to be sequenced, provides the necessary resource for whole-genome comparative analysis of gene sequence evolution...
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Article
Open AccessThe genome of a songbird
The genome of the zebra finch — a songbird and a model for the study of vertebrate brain, behaviour and evolution — has been sequenced. Its comparison with the chicken genome, the only other bird genome availa...
