8 Result(s)
within
Axel Haverich
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessBulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
In vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of human embryogenesis, but the underlying processes are poorly understood and controlled. Here we show that modulating...
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Article
Open AccessUse of sucrose to diminish pore formation in freeze-dried heart valves
Freeze-dried storage of decellularized heart valves provides easy storage and transport for clinical use. Freeze-drying without protectants, however, results in a disrupted histoarchitecture after rehydration....
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Article
Open AccessFibrin glue as a local drug-delivery system for bacteriophage PA5
Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as a medium for local, prolonged drug delivery. Effective local delivery of antibacteria...
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Article
Open AccessFormation of three-dimensional tubular endothelial cell networks under defined serum-free cell culture conditions in human collagen hydrogels
Implementation of tubular endothelial cell networks is a prerequisite for 3D tissue engineering of constructs with clinically relevant size as nourishment of cells is challenged by the diffusion limit. In vitro g...
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Article
Open AccessGenetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung
Previous studies have demonstrated substantial genetic diversification of Pseudomonas aeruginosa across sub-compartments in cystic fibrosis (CF) lungs. Here, we isolate P. aeruginosa from five different sampling ...
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Article
Open AccessLow immunogenic endothelial cells endothelialize the Left Ventricular Assist Device
Low haemocompatibility of left ventricular assist devices (LVAD) surfaces necessitates anticoagulative therapy. Endothelial cell (EC) seeding can support haemocompatibility, however, the availability of autolo...
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Article
Open AccessEstablishment of a guided, in vivo, multi-channel, abdominal, tissue imaging approach
Novel tools in humane animal research should benefit the animal as well as the experimentally obtained data. Imaging technologies have proven to be versatile and also in accordance with the demands of the 3 R ...
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Article
Open AccessInterplay between driveline infection, vessel wall inflammation, cerebrovascular events and mortality in patients with left ventricular assist device
In patients with left ventricular assist device (LVAD), infections and thrombotic events represent severe complications. We investigated device-specific local and systemic inflammation and its impact on cerebr...
