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Article
Low E-cadherin and β-catenin expression correlates with increased spontaneous and artificial lung metastases of murine carcinomas
This study examined the relationship between the expression of E-cadherin or β-catenin in murine adenocarcinomas and their hematogenous metastatic propensity, assessed by both spontaneous and artificial lung m...
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Article
Diagnostisches und therapeutisches Management der oberen Einflußstauung
Der oberen Einflußstauung (Vena-cava-superior-Syndrom) liegt in über 80% der Fälle ein maligner Tumor zugrunde, und nicht selten stellt diese Komplikation das erste Symptom des Malignoms dar.
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Article
C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines
The over-expression of c-erbB-2/ HER-2, a receptor tyrosine kinase, correlates with poor prognosis in patients with breast and ovarian cancer. In the human breast cancer cell line, MDA-MB-435, c-erbB-2 over-ex...
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Article
A low dose of ionizing radiation increases luminal release of intestinal peptidases in rats
Purpose: Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal relea...
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Article
Cyclooxygenase-2: a novel target for cancer chemotherapy?
Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs are known to inhibit cyclooxygenases...
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Article
Defizite in der Behandlung von Patienten mit kolorektalem Karzinom in Deutschland Ergebnisse einer multizentrischen Dokumentation von Therapiealgorithmen
Hintergrund: Seit etwa 10 Jahren existieren Konsensusempfehlungen zur adjuvanten Therapie des lokal fortgeschrittenen kolorektalen Karzinoms (amerikanisches National Institute of Health 1990, Deu...
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Article
Defizite in der Behandlung von Patienten mit kolorektalem Karzinom in Deutschland
Seit etwa 10 Jahren existieren Konsensusempfehlungen zur adjuvanten Therapie des lokal fortgeschrittenen kolorektalen Karzinoms (amerikanisches National Institute of Health 1990, Deutsche Krebsgesellschaft 199...
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Chapter and Conference Paper
Chemotherapy in Merkel Cell Carcinoma with Distant Metastasis — Proposal of a Pan-European Clinical Trial
Merkel cell carcinoma (MCC) is a rare and highly malignant neuroendocrine skin tumour characterized by a high frequency of metastases (Helmbold et al. 2001). The 5-year survival rate is stage-dependent and ran...
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Article
Costs of treatment of colorectal cancer in different settings in Germany
The objective of this study was to evaluate the cost implications of different settings (inpatient, outpatient/day clinic, or office-based oncologists) for the administration of standard fluoropyrimidine thera...
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Article
Granisetron versus tropisetron for prophylaxis of acute chemotherapy-induced emesis: a pooled analysis
This analysis compares the antiemetic efficacy of the 5-HT3-receptor antagonists granisetron and tropisetron in acute chemotherapy-induced nausea and vomiting (CINV). All published randomized studies comparing gr...
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Article
Clinical Trial Designs for Prospective Validation of Biomarkers
Traditionally, anatomic staging systems have been used to determine predictions of individual patient outcome and, to a lesser extent, guide the choice of treatment in patients with cancer. With new targeted t...
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Article
Does bevacizumab improve survival in patients with metastatic colorectal cancer treated with chemotherapy?
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Article
Should bevacizumab be continued beyond progression in colorectal cancer?
Medical therapy for advanced colorectal cancer has seen significant changes over the past decade. Most recently, molecular targeted agents such as antibodies against the epidermal growth factor receptor and th...
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Article
A comparison of XELOX with FOLFOX-4 as first-line treatment for metastatic colorectal cancer
Oral capecitabine has been shown to be a convenient and well tolerated alternative to intravenous 5-fluorouracil (5-FU) in the treatment of colorectal cancer. The question of whether capecitabine is an adequat...
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Article
Adding cetuximab to a standard chemotherapy regimen containing bevacizumab in first-line therapy for colorectal cancer decreases efficacy: Results from the CAIRO2 trial
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Article
Targeting angiogenesis: progress with anti-VEGF treatment with large molecules
Bevacizumab has improved survival outcomes in patients with various solid tumors when combined with chemotherapy. The authors discuss the rationale for using bevacizumab and other large-molecule agents that ta...
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Article
Biomarkers and surrogate end points—the challenge of statistical validation
The validation of predictive and prognostic biomarkers and surrogate end points requires robust statistical analysis of data gathered from multiple, large, independent studies. In this Review, Marc Buyse and c...
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Article
Strategies for Managing Chemotherapy-Induced Sensory Neuropathy
Chemotherapy-induced sensory neuropathy occurs in most patients undergoing treatment with oxaliplatin for colorectal cancer. Although the acute form of neurotoxicity is transient, the chronic form, which is co...
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Article
Curable Metastatic Colorectal Cancer
In the United States and Europe, colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related death for men and women. In the course of their disease, many patient...
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Article
Reduced Chemotherapy Duration: A Good Idea?
Over the past three decades, survival outcomes of high-risk stage II and stage III colon cancer have improved with the use of adjuvant chemotherapy. Oxaliplatin and fluoropyrimidine combination regimens, given...
