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Article
Open AccessDysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson’s disease
Since the identification of vacuolar protein sorting (VPS) 35, as a causative molecule for familial Parkinson’s disease (PD), retromer-mediated endosomal machinery has been a rising factor in the pathogenesis ...
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Article
Open AccessStraightforward and affordable agroinfiltration with RUBY accelerates RNA silencing research
Transient expression and induction of RNA silencing by agroinfiltration is a fundamental method in plant RNA biology. Here, we introduce a new reporter assay using RUBY, which encodes three key enzymes of the ...
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Article
Left-atrial volume reduction reflects improvement of cardiac sympathetic nervous function in patients with severe aortic stenosis after transcatheter aortic valve replacement
Trans-catheter aortic valve replacement (TAVR) is an excellent alternative intervention for surgical aortic valve replacement. Cardiac sympathetic nervous (CSN) function and left atrial (LA) volume are both im...
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Article
Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk
Mobile genetic elements (MEs) are heritable mutagens that recursively generate structural variants (SVs). ME variants (MEVs) are difficult to genotype and integrate in statistical genetics, obscuring their imp...
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Article
Open AccessMetallothionein synthesis increased by Nin**-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β1-42
It is possible that increased synthesis of metallothioneins (MTs), Zn2+-binding proteins is linked with the protective effect of Nin**-yoei-to (NYT) on Zn2+ toxicity ferried by amyloid β1-42 (Aβ1-42).
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Article
Involvement of isoproterenol-induced intracellular Zn2+ dynamics in the basolateral amygdala in conditioned fear memory
Beta-adrenergic receptors in the basolateral amygdala play an essential role in fear memory, while the physiological role of intracellular Zn2+ remains to be clarified. Intracellular Zn2+ level was decreased 5 mi...
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Article
Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats
Coriandrum sativum L. (coriander), which is an annual herb of the Apiaceae family, has been traditionally used as a remedy. Here we tested whether heated extract of coriander leaf protects nigral dopaminergic neu...
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Article
Isoproterenol, an adrenergic β receptor agonist, induces metallothionein synthesis followed by canceling amyloid β1-42-induced neurodegeneration
Adrenergic β receptor activation may ameliorate amyloid β toxicity. We examined whether isoproterenol, an adrenergic β receptor agonist reduces neurodegeneration caused by Aβ1-42, for which intracellular Zn2+ dys...
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Chapter and Conference Paper
Detection and Analysis of Intrusion Attacks Using Deep Neural Networks
Intrusion detection systems are becoming more necessary because the number of intrusion attacks on servers is increasing. Attackers try to intrude on the servers in various ways. Therefore, intrusion detection...
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Protocol
Bioinformatics Approaches for Determining the Functional Impact of Repetitive Elements on Non-coding RNAs
With a large number of annotated non-coding RNAs (ncRNAs), repetitive sequences are found to constitute functional components (termed as repetitive elements) in ncRNAs that perform specific biological function...
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Article
High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome
Hashimoto’s encephalopathy with serum anti-NH2-terminal of α-enolase (NAE) antibodies occasionally displays clinical symptoms such as cerebellar ataxia and parkinsonism. We studied the frequency of anti-NAE antib...
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Article
Dehydroeffusol Pprevents Amyloid β1-42-mediated Hippocampal Neurodegeneration via Reducing Intracellular Zn2+ Toxicity
Dehydroeffusol, a phenanthrene isolated from Juncus effusus, is a Chinese medicine. To explore an efficacy of dehydroeffusol administration for prevention and cure of Alzheimer’s disease, here we examined the eff...
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Article
Open AccessIntrinsic motivation in patients with Parkinson’s disease: a neuropsychological investigation of curiosity using dopamine transporter imaging
Both intrinsic and extrinsic motivation are believed to involve brain regions that are innervated by the dopaminergic pathway. Although dopaminergic neurons in the midbrain deteriorate in Parkinson’s disease (...
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Article
Open AccessPersistent directional growth capability in Arabidopsis thaliana pollen tubes after nuclear elimination from the apex
During the double fertilization process, pollen tubes deliver two sperm cells to an ovule containing the female gametes. In the pollen tube, the vegetative nucleus and sperm cells move together to the apical r...
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Article
Open AccessLong-term safety and efficacy of opicapone in Japanese Parkinson’s patients with motor fluctuations
The double-blind part of the COMFORT-PD (COMt-inhibitor Findings from Opicapone Repeated Treatment for Parkinson’s Disease) study in Japanese levodopa-treated patients with Parkinson’s disease and motor fluctu...
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Article
Extracellular Zn2+-Dependent Amyloid-β1–42 Neurotoxicity in Alzheimer’s Disease Pathogenesis
The basal level of extracellular Zn2+ is in the range of low nanomolar (~ 10 nM) in the hippocampus. However, extracellular Zn2+ dynamics plays a key role for not only cognitive activity but also cognitive declin...
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Article
Alzheimer risk factors age and female sex induce cortical Aβ aggregation by raising extracellular zinc
Aging and female sex are the major risk factors for Alzheimer’s disease and its associated brain amyloid-β (Aβ) neuropathology, but the mechanisms mediating these risk factors remain uncertain. Evidence indica...
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Article
Dehydroeffusol Rescues Amyloid β25–35-Induced Spatial Working Memory Deficit
Amyloid β (Aβ) peptides produced from the amyloid precursor protein, a transmembrane protein, are neurotoxic and blocking the neurotoxicity may lead to prevention of Alzheimer’s disease (AD). Here we tested wh...
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Article
Preferential Neurodegeneration in the Dentate Gyrus by Amyloid β1–42-Induced Intracellular Zn2+Dysregulation and Its Defense Strategy
On the basis of the evidence that rapid intracellular Zn2+ dysregulation by amyloid β1–42 (Aβ1–42) in the normal hippocampus transiently induces cognitive decline, here we report preferential neurodegeneration in...
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Article
Paraquat as an Environmental Risk Factor in Parkinson’s Disease Accelerates Age-Related Degeneration Via Rapid Influx of Extracellular Zn2+ into Nigral Dopaminergic Neurons
On the basis of the evidence that paraquat (PQ)-induced extracellular Zn2+ influx causes PQ-induced pathogenesis in the substantia nigra pars compacta (SNpc) of rats, we postulated that the transient receptor pot...
