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Article
Open AccessA randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC)
Therapeutic options for early-stage hepatocellular carcinoma (HCC) in individual patients can be limited by tumor and location, liver dysfunction and comorbidities. Many patients with early-stage HCC do not re...
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Article
A clinical study on roxadustat for anemia in diabetic nephropathy: a 8-week study
The development of roxadustat is a standard treatment for renal anemia, and multiple clinical trials have proved its safety and efficacy. However, less information is available from trials of the population wi...
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Article
Open AccessEffect of roxadustat on iron metabolism in patients with peritoneal dialysis: a real-world 24-week study
Roxadustat is an oral hypoxia inducing factor-prolyl hydroxylase inhibitor (HIF-PHI) that regulates iron metabolism in patients with chronic kidney disease (CKD) primarily by reducing hepcidin levels and mobil...
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Article
Open AccessEffects of Erythrocytapheresis Procedures on Delayed Bone Marrow Conversion in Sickle Cell Disease
The imaging appearances of the skeletal system have been well documented in sickle cell disease (SCD) but there is limited information about the impact of SCD treatments on skeletal abnormalities. We present t...
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Article
Open AccessA 3D printing personalized percutaneous puncture guide access plate for percutaneous nephrolithotomy: a pilot study
CT-Urography combined with 3D printing technology, digital design, construction of individualized PCNL puncture guides, and preliminary analyze their efficacy, safety puncture positioning for PCNL.
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Article
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinicall...
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Article
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and p...
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Article
Demonstration of biocompatibility of single walled carbon nanotubes with blood leukocytes
Single walled carbon nanotubes (SWNTs) possess unique structural and functional properties. Their ability to be functionalized with different biomolecules makes them excellent candidates for biomedical applica...
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Article
Exploiting osmosis for blood cell sorting
Blood is a valuable tissue containing cellular populations rich in information regarding the immediate immune and inflammatory status of the body. Blood leukocytes or white blood cells (WBCs) provide an ideal ...
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Article
Clinical application of microfluidic leukocyte enrichment protocol in mild phenotype sickle cell disease (SCD)
Nucleated cell populations, including leukocytes and circulating endothelial cells, provide an ideal sample for studies seeking to understand the pathogenesis of diseases for development of drugs and treatment...
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Article
Sponsored R&D in India: The project sponsoring pattern and main outcome of projects sponsored by major central departments/agencies
This paper examines the project sponsoring pattern and the outcome of extramural R&D with respect to the projects sponsored by country's eleven central agencies during the Seventh Five-Year Plan period. The ou...
