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Article
Open AccessMitochondrial heteroplasmic shifts reveal a positive selection of breast cancer
Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic information in circulation. Unlike single-copy nuclear DNA, mitochondrial DNA ...
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Article
Open AccessThe association of zonulin-related proteins with prevalent and incident inflammatory bowel disease
Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of...
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Article
Open AccessAssociation of circulating let-7b-5p with major depressive disorder: a nested case-control study
Major depressive disorder (MDD) is one of the most common psychiatric disorders and is a great disease burden. However, its underlying pathophysiology and aetiology remain poorly understood. Available evidence...
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Article
Open AccessMitochondria-DNA copy-number and incident venous thromboembolism among middle-aged women: a population-based cohort study
Venous thromboembolism (VTE) is the third most common cardiovascular disease. Low amount of mitochondrial DNA copy number (mtDNA-CN) has been associated with arterial cardiovascular disease (CVD) and reflects ...
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Article
Open AccessElucidating causal effects of type 2 diabetes on ischemic heart disease from observational data on middle-aged Swedish women: a triangular analytical approach
The association between type 2 diabetes (T2D) and ischemic heart disease (IHD) is well established but the potential causal association needs further studying. In an attempt to elucidate the causal effect of T...
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Article
Open AccessAssociation of mitochondrial DNA copy number with prevalent and incident type 2 diabetes in women: A population-based follow-up study
Mitochondrial dysfunction is an important factor of the aging process and may play a key role in various diseases. Mitochondrial DNA copy number (mtDNA-CN) is an indirect measure of mitochondrial dysfunction a...
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Article
Open AccessMacrophage Migration Inhibitory Factor as a Predictor for Long-term Improvements After Mindfulness-Based Group Therapy or Treatment as Usual for Depression, Anxiety or Stress and Adjustment Disorders
Identification of biological markers that can guide treatment selection is considered to be a viable solution for personalized treatment for patients with psychiatric disorders. This study investigated whether...
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Article
Open AccessAssociation of recurrent venous thromboembolism and circulating microRNAs
Patients with unprovoked first venous thromboembolism (VTE) are at a high risk of recurrence. Although circulating microRNAs (miRNAs) have been found to be associated with VTE and are markers of hypercoagulabi...
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Article
Open AccessRisk prediction of recurrent venous thromboembolism: a multiple genetic risk model
A single genetic biomarker is unable to accurately predict the risk for venous thromboembolism (VTE) recurrence. We aimed to: (a) develop a multiple single nucleotide polymorphisms (SNPs) model to predict the ...
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Article
Open AccessPolymorphisms in PARK2 and MRPL37 are associated with higher risk of recurrent venous thromboembolism in a sex-specific manner
Recent studies indicate that mitochondrial DNA (mtDNA) dysfunction is a biomarker of oxidative stress and can predict the risk of cardiovascular diseases (CVDs). Genetic variants in PARK2 (rs4708928) and MRPL37 (...
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Article
Open AccessAssociation between TLR9 rs5743836 polymorphism and risk of recurrent venous thromboembolism
Recent gene knockout studies on mice have shown the role of toll-like receptor 9 (TLR9) in resolution of venous thromboembolism (VTE) through sterile inflammation. However, the role of a putative functional TLR9 ...
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Article
Open AccessLeukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients
The primary aim was to examine possible differences in telomere length between primary health care patients, with depression, anxiety or stress and adjustment disorders, and healthy controls. The second aim wa...
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Article
Open AccessPalaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial
We have previously shown that a Palaeolithic diet consisting of the typical food groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease risk factors and glucose control comp...
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Article
Open AccessWomen’s health in the Lund area (WHILA) - Alcohol consumption and all-cause mortality among women – a 17 year follow-up study
Alcohol consumption contributes to many negative health consequences and is a risk factor for death. Some previous studies however suggest a J-shaped relationship between the level of alcohol consumption and a...
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Article
Open AccessYoga’s effect on inflammatory biomarkers and metabolic risk factors in a high risk population – a controlled trial in primary care
Yoga can reduce blood pressure and has also been suggested to reduce inflammatory biomarkers and metabolic risk factors for cardiovascular diseases (CVDs). We aimed to assess the benefit of two yoga interventi...
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Article
Open AccessCirculating microRNA-144-5p is associated with depressive disorders
Depressive/anxiety disorders are the most common types of mental illnesses in the world. The present study was the first to explore the association between plasma microRNAs (miRNAs) and depression/anxiety in p...
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Article
Open AccessDigested wheat gluten inhibits binding between leptin and its receptor
Leptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor. No...
