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Article
Open AccessXpert HIV-1 qual point-of-care testing for HIV early infant diagnosis in Tanzania: experiences and perceptions of health care workers in a 2016 study
HIV early infant diagnosis (HEID) at the centralized laboratory faces many challenges that impact the cascade of timely HEID. Point of Care (PoC) HEID has shown to reduce test turnaround times, allow for task ...
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Article
Open AccessLong-term monitoring of SARS-CoV-2 seroprevalence and variants in Ethiopia provides prediction for immunity and cross-immunity
Under-reporting of COVID-19 and the limited information about circulating SARS-CoV-2 variants remain major challenges for many African countries. We analyzed SARS-CoV-2 infection dynamics in Addis Ababa and Ji...
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Article
Open AccessDynamics and durability of HIV-1 neutralization are determined by viral replication
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet available, only data from ...
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Article
Open AccessDepression management and antiretroviral treatment outcome among people living with HIV in Northwest and East regions of Cameroon
Several interventions have shown benefits in improving mental health problems such as depression which is common in people living with HIV. However, there is a paucity of evidence on the effect of these interv...
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Article
Open AccessLong-term follow-up on HIV infected and non-infected women with cervical cancer from Tanzania: staging, access to cancer-directed therapies and associated survival in a real-life remote setting
Worldwide 85% of cervical cancer (CC) related deaths occur in low- and middle-income countries. Sub-Saharan Africa is burdend by an overlap** high incidence of CC as well as HIV infection, a risk factor for ...
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Article
Open AccessCosts and cost-effectiveness of HIV early infant diagnosis in low- and middle-income countries: a sco** review
Continuing progress in the global pediatric human immunodeficiency virus (HIV) response depends on timely identification and care of infants with HIV. As countries scale-out improvements to HIV early infant di...
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Article
Open AccessSafety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2
We used the RNActive® technology platform (CureVac N.V., Tübingen, Germany) to prepare CVnCoV, a COVID-19 vaccine containing sequence-optimized mRNA coding for a stabilized form of SARS-CoV‑2 spike (S) protein...
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Article
Open AccessUsing a composite adherence tool to assess ART response and risk factors of poor adherence in pregnant and breastfeeding HIV-positive Cameroonian women at 6 and 12 months after initiating option B+
Antiretroviral therapy (ART) adherence in preventing HIV mother-to-child transmission in association with virological suppression and risk factors of low adherence in the Cameroon’s Option B+ programme are poo...
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Article
Open AccessEvidence for significant influence of host immunity on changes in differential blood count during malaria
Malaria has been shown to change blood counts. Recently, a few studies have investigated the alteration of the peripheral blood monocyte-to-lymphocyte count ratio (MLCR) and the neutrophil-to-lymphocyte count ...
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Article
Open AccessNon-healing old world cutaneous leishmaniasis caused by L. infantumin a patient from Spain
The prevalence of Old World Cutaneous Leishmaniasis in the Mediterranean region is increasing and in Southern Europe often caused by Leishmania infantum. Spontaneous healing of cutaneous leishmaniasis is commonly...
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Retroviral B7.1 Gene Transfer in Cancer Cells Protects Cytotoxic T Cells from Deletion by “Veto” Apoptosis
It is generally accepted that T cell activation requires two distinct signals. The first signal is dependent on the ligation of the T cell receptor (TCR)/CD3 complex and the CD4 and CD8 co-receptors [1]. The s...
