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Article
Open AccessEndoscopic resection with adjuvant treatment versus esophagectomy for early-stage esophageal cancer
To evaluate the outcome following the strategy of endoscopic R0 resection (ER) plus adjuvant treatment (AT) versus esophagectomy for esophageal squamous cell cancer in T1a invading muscularis mucosa (M3)-T1b s...
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Chapter
Transhiatal Esophagectomy
There are several approaches to esophageal resection, with the two primary approaches being a transhiatal approach and a transthoracic approach. Over the past several years, refinement of the operative techniq...
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Article
Open AccessThe ideal approach for treatment of cT1N+ and cT2Nany esophageal cancer.: a NCDB analysis
Neoadjuvant therapy followed by surgery is recommended for locally advanced esophageal cancer. With the inaccuracies of clinical staging particularly for cT1N+ and cT2Nany tumors, some have proposed considerat...
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Article
Pten-NOLC1 fusion promotes cancers involving MET and EGFR signalings
Inactivation of Pten gene through deletions and mutations leading to excessive pro-growth signaling pathway activations frequently occurs in cancers. Here, we report a Pten derived pro-cancer growth gene fusion P...
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Article
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion
Regulatory T cells (Treg cells) maintain host self-tolerance but are a major barrier to effective cancer immunotherapy. Treg cells subvert beneficial anti-tumor immunity by modulating inhibitory receptor expressi...
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Article
Open AccessIdentification of recurrent fusion genes across multiple cancer types
Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer gen...
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Article
Open AccessCyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies
Cyclin E is a cell cycle regulator which is critical for driving G1/S transition. Abnormal levels of cyclin E have been found in many cancers. However, the level changes of cyclin E in esophageal adenocarcinom...
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Article
Open AccessF-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation
Rac3 is a small GTPase multifunctional protein that regulates cell adhesion, migration, and differentiation. It has been considered as an oncogene in breast cancer; however, its role in esophageal cancer and t...
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Article
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
Adam Bass, Gad Getz and colleagues report whole-exome sequencing of 149 esophageal adenocarcinomas (EACs) and whole-genome sequencing of 15 EACs. They identify a mutational signature defined by a high prevalen...
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Article
Open AccessClinicopathologic characteristics of high expression of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma
High expression of Bmi-1, a key regulatory component of the polycomb repressive complex-1, has been associated with many solid and hematologic malignancies including esophageal squamous cell carcinoma. However...
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Article
Minimally Invasive Esophagectomy for Barrett's with High-grade Dysplasia and Early Adenocarcinoma of the Esophagus
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Article
Minimally Invasive Surgical Treatment of Sigmoidal Esophagus in Achalasia
The appropriate surgical intervention for sigmoidal esophagus in the setting of achalasia remains controversial. The objective of this study is to review our experience with minimally invasive myotomy (MIM) an...
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Article
Laparoscopic Repair of Giant Paraesophageal Hernia Results in Long-Term Patient Satisfaction and a Durable Repair
Laparoscopic repair of giant paraesophageal hernia (LRGPEH) is routinely performed in many centers, but high recurrence rates have led to concerns regarding this approach. We evaluate long-term recurrence rate...
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Article
Minimally invasive myotomy for achalasia in the elderly
Elderly patients with achalasia are more frequently being referred for minimally invasive Heller myotomy (MIM). The associated morbidity and mortality of MIM in the elderly are not well defined. The objective ...
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Article
Obesity Correlates with Gastroesophageal Reflux
Thirty morbidly obese patients presenting forbariatric surgery were evaluated for symptomatic andobjective evidence of gastroesophageal reflux. Sixteenpatients had heartburn while 14 were asymptomatic. All und...
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Chapter and Conference Paper
Esophageal Trauma: A Modern Perspective
Esophageal trauma remains a diagnostic and therapeutic challenge. This is reflected by reported mortality rates of 15%–20% which have remained unchanged for several decades. Outcome is clearly influenced by se...
