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Open AccessSubcellular glucose exposure biases the spatial distribution of insulin granules in single pancreatic beta cells
In living tissues, a cell is exposed to chemical substances delivered partially to its surface. Such a heterogeneous chemical environment potentially induces cell polarity. To evaluate this effect, we develope...
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Localized substance delivery to single cell and 4D imaging of its uptake using a flow channel with a lateral aperture
We have developed a novel microfluidic device for space- and time-resolved (4D) visualization of intracellular events when a cell surface is partially exposed to external stimuli. The device, fabricated using ...
