Raynaud’s Phenomenon
From Pathogenesis to Management
Article
The identification of novel risk variants in the largest genome-wide association study of Raynaud phenomenon to date provides insights into the pathophysiology of the condition, including the potential role for α
Chapter
Lower limb ulcers are uncommon in patients with systemic sclerosis (SSc), but when they do occur can be very difficult to heal due to a combination of poor blood supply and (in some patients) the tightness of ...
Book
Chapter
This chapter addresses the two main questions posed when a patient presents with Raynaud’s phenomenon (RP). First: ‘Why does this patient have RP? Is it primary (idiopathic) or secondary, and if secondary, to ...
Chapter
Raynaud’s phenomenon (RP) may warrant pharmacological treatment if there are significant symptoms not controlled by nonpharmacological treatment or complications. The principles of RP treatment are to decrease...
Chapter
Skin thickening of early diffuse cutaneous systemic sclerosis (dcSSc) is in itself a major source of pain, disability, and disfigurement. Skin involvement progresses and then tends to plateau, usually within t...
Article
Systemic sclerosis (SSc)-related digital ischaemia is a major cause of morbidity, resulting from a combination of microvascular and digital artery disease. Photoacoustic imaging offers a newly available, non-i...
Article
Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed tot...
Article
Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality resulting from early internal-organ involvement. Clinicians therefore tend to focus on early diagnosis and treatment of potentiall...
Chapter
Calcinosis (subcutaneous or intracutaneous deposition of calcium salts) is a significant clinical problem in over 20% of patients with systemic sclerosis (SSc). It is often painful (especially when calcium lum...
Article
The autoimmune disease systemic sclerosis (SSc) causes microvascular changes that can be easily observed cutaneously at the finger nailfold. Optoacoustic imaging (OAI), a combination of optical and ultrasound ...
Article
Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previou...
Article
Article
To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distin...
Chapter
Raynaud’s phenomenon (RP) is a common condition which can occur either primary (idiopathic) or secondary to a wide range of conditions or drug therapies. In patients with systemic sclerosis (SSc), RP occurs wi...
Chapter
Although most patients with systemic sclerosis (SSc)-related digital ulcers respond to medical management, a small but significant proportion benefit from surgical treatment. In our opinion the key aspect to s...
Article
To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud’s phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapil...
Book
Chapter
Microvascular abnormalities are a key feature of systemic sclerosis and typically occur early in the disease course. Nailfold capillaroscopy is a noninvasive clinically useful tool that can provide valuable in...
Article
This review focuses on new findings and developments relevant to the clinician caring for patients with primary and secondary [especially systemic sclerosis (SSc)-related] Raynaud phenomenon (RP). In the last ...