Raynaud’s Phenomenon
From Pathogenesis to Management
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21 Result(s)
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Article
Raynaud phenomenon: from GWAS to drug repurposing
The identification of novel risk variants in the largest genome-wide association study of Raynaud phenomenon to date provides insights into the pathophysiology of the condition, including the potential role for α
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Chapter
Lower Limb Ulceration
Lower limb ulcers are uncommon in patients with systemic sclerosis (SSc), but when they do occur can be very difficult to heal due to a combination of poor blood supply and (in some patients) the tightness of ...
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Practical Approach to the Patient with Raynaud’s Phenomenon: Primary Versus Secondary Raynaud’s Phenomenon
This chapter addresses the two main questions posed when a patient presents with Raynaud’s phenomenon (RP). First: ‘Why does this patient have RP? Is it primary (idiopathic) or secondary, and if secondary, to ...
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Chapter
Drug Therapy
Raynaud’s phenomenon (RP) may warrant pharmacological treatment if there are significant symptoms not controlled by nonpharmacological treatment or complications. The principles of RP treatment are to decrease...
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Chapter
Management of Progressive Skin Involvement in Diffuse Scleroderma
Skin thickening of early diffuse cutaneous systemic sclerosis (dcSSc) is in itself a major source of pain, disability, and disfigurement. Skin involvement progresses and then tends to plateau, usually within t...
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Article
Skin involvement in early diffuse cutaneous systemic sclerosis: an unmet clinical need
Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality resulting from early internal-organ involvement. Clinicians therefore tend to focus on early diagnosis and treatment of potentiall...
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Chapter
Calcinosis
Calcinosis (subcutaneous or intracutaneous deposition of calcium salts) is a significant clinical problem in over 20% of patients with systemic sclerosis (SSc). It is often painful (especially when calcium lum...
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Article
Open AccessType I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles
To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distin...
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Chapter
Raynaud’s Phenomenon and Ulcers
Raynaud’s phenomenon (RP) is a common condition which can occur either primary (idiopathic) or secondary to a wide range of conditions or drug therapies. In patients with systemic sclerosis (SSc), RP occurs wi...
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Chapter
Surgical Approaches Including Sympathectomy
Although most patients with systemic sclerosis (SSc)-related digital ulcers respond to medical management, a small but significant proportion benefit from surgical treatment. In our opinion the key aspect to s...
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Article
An international SUrvey on non-iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud’s phEnomenon (SUNSHINE survey)
To canvas opinion concerning the role of non-invasive techniques in the assessment of patients with Raynaud’s phenomenon (Rp) in clinical and research settings: four nailfold capillaroscopy methods [videocapil...
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Book
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Chapter
Nailfold Capillaroscopy
Microvascular abnormalities are a key feature of systemic sclerosis and typically occur early in the disease course. Nailfold capillaroscopy is a noninvasive clinically useful tool that can provide valuable in...
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Article
Management of Raynaud’s Phenomenon and Digital Ischemia
This review focuses on new findings and developments relevant to the clinician caring for patients with primary and secondary [especially systemic sclerosis (SSc)-related] Raynaud phenomenon (RP). In the last ...
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Article
The pathogenesis, diagnosis and treatment of Raynaud phenomenon
Recent advances in pathogenesis and diagnosis of Raynaud phenomenon have driven, and are driving, new therapeutic strategies for this phenomenon. In this Review, Ariane Herrick provides an update of the pathog...
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Chapter
Raynaud’s Phenomenon
A 38-year-old female patient presented to the rheumatology clinic with a 3-week history of a painful fingertip ulcer. The pain was so severe that it was kee** her awake at night. For 20 years (since her teen...
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Chapter
A 22-Year-Old Woman with Raynaud’s Phenomenon but No Other Symptoms and No Abnormalities on Examination
Raynaud’s phenomenon, episodic color change of the fingers usually in response to cold exposure, can be either primary (idiopathic: PRP) or secondary to an underlying disease or condition, for example, to a sy...
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Article
A local approach to Raynaud phenomenon
The current treatment options for Raynaud phenomenon are often ineffective and can have undesirable adverse effects. Topical, or transdermal, treatments that increase digital blood flow without systemic advers...
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Article
Genetic epidemiology: Systemic sclerosis
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterised phenotypically by fibrosis and ischaemic atrophy. Its aetiology is most likely multifactorial. A genetic predisposition to the ...
