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Article
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) bl...
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Article
A three-drug combination to treat BRAF-mutant cancers
A new study that uses a triple-drug combination to overcome a major mechanism of drug resistance in cancer provides insights into the evolutionary paths taken by tumors in the face of selective pressure.
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Article
Open AccessKRAS insertion mutations are oncogenic and exhibit distinct functional properties
Oncogenic KRAS mutations introduce discrete amino acid substitutions that reduce intrinsic Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs). Here we discover a partial duplication of...
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Article
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
A family of small molecules called ‘ciliobrevins’ are described that can rapidly and reversibly modulate the AAA+ ATPase motor dynein, which transports cargo molecules along microtubule tracks.
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Chapter
Small-Molecule Inhibitors of the Hedgehog Pathway
The causal link between uncontrolled Hedgehog (Hh) pathway activation and oncogenesis has inspired the development of small-molecule inhibitors of this developmental signaling pathway. In this chapter, we disc...
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Article
Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions
The ability of cells to form cell contacts, adhere to the extracellular matrix, change morphology, and migrate is essential for development, wound healing, metastasis, cell survival and the immune response. Th...