Skip to main content

6 Result(s)

within Ari J. Firestone Remove this filter

and

  1. No Access

    Article

    ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

    Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) bl...

    Jarrett R. Remsberg, Radu M. Suciu, Noemi A. Zambetti… in Nature Chemical Biology (2021)

  2. No Access

    Article

    A three-drug combination to treat BRAF-mutant cancers

    A new study that uses a triple-drug combination to overcome a major mechanism of drug resistance in cancer provides insights into the evolutionary paths taken by tumors in the face of selective pressure.

    Ari J Firestone, Jeff Settleman in Nature Medicine (2017)

  3. Article

    Open Access

    KRAS insertion mutations are oncogenic and exhibit distinct functional properties

    Oncogenic KRAS mutations introduce discrete amino acid substitutions that reduce intrinsic Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs). Here we discover a partial duplication of...

    Yasmine White, Aditi Bagchi, Jessica Van Ziffle, Anagha Inguva… in Nature Communications (2016)

    Download PDF (970 KB) View Article

  4. No Access

    Article

    Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

    A family of small molecules called ‘ciliobrevins’ are described that can rapidly and reversibly modulate the AAA+ ATPase motor dynein, which transports cargo molecules along microtubule tracks.

    Ari J. Firestone, Joshua S. Weinger, Maria Maldonado, Kari Barlan… in Nature (2012)

  5. No Access

    Chapter

    Small-Molecule Inhibitors of the Hedgehog Pathway

    The causal link between uncontrolled Hedgehog (Hh) pathway activation and oncogenesis has inspired the development of small-molecule inhibitors of this developmental signaling pathway. In this chapter, we disc...

    Ari J. Firestone, James K. Chen in Hedgehog signaling activation in human can… (2011)

  6. No Access

    Article

    Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

    The ability of cells to form cell contacts, adhere to the extracellular matrix, change morphology, and migrate is essential for development, wound healing, metastasis, cell survival and the immune response. Th...

    Kun Ling, Renee L. Doughman, Ari J. Firestone, Matthew W. Bunce… in Nature (2002)