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Article
Antibody–drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry
Engineering approaches using antibody drug conjugates (ADCs) and bispecific antibodies (bsAbs) are designed to overcome the limitations of conventional chemotherapies and therapeutic antibodies such as drug re...
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Article
A curcumin analog CA-5f inhibits urokinase-type plasminogen activator and invasive phenotype of triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is one of the most aggressive types of breast cancer with poor outcomes. Patients with TNBC cannot benefit from targeted therapies such as Tamoxifen and Herceptin. The aim ...
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Article
CCL8 mediates crosstalk between endothelial colony forming cells and triple-negative breast cancer cells through IL-8, aggravating invasion and tumorigenicity
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with a poor prognosis for which no effective therapeutic measures are currently available. The present study aimed to investigate whe...
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Chapter
Ras Signaling in Breast Cancer
Ras proteins mediate extracellular and cytoplasmic signaling networks via receptor tyrosine kinase. The Ras pathway induces activation of signaling molecules involved in cell proliferation and growth, cell sur...
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Article
Open AccessMolecular Markers in Sex Differences in Cancer
Cancer is one of the common causes of death with a high degree of mortality, worldwide. In many types of cancers, if not all, sex-biased disparities have been observed. In these cancers, an individual’s sex ha...
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Article
Correction to: Crosstalk between cancer cells and endothelial cells: implications for tumor progression and intervention
Unfortunately, there is an error in the original version of the article. The original published article contains an incomplete ‘Acknowledgements’ section. Please find the full ‘Acknowledgements’ section below.
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Article
Crosstalk between cancer cells and endothelial cells: implications for tumor progression and intervention
Communication between tumor cells and stromal cells is crucial to tumor development and progression. Fibroblasts and macrophages are the most common stromal cells in the tumor microenvironment. Endothelial cel...
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Article
Selenium-binding protein 1: a sensitive urinary biomarker to detect heavy metal-induced nephrotoxicity
Identifying novel biomarkers to detect nephrotoxicity is clinically important. Here, we attempted to identify new biomarkers for mercury-induced nephrotoxicity and compared their sensitivity to that of traditi...
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Article
Inflammatory fibroblasts in cancer
The association between inflammation and cancer has been studied widely. Indeed, the tumor microenvironment is influenced by inflammatory cells and affects tumor progression, tumor growth, and the survival of ...
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Article
Open AccessPyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury
The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidit...
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Article
Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
Cordyceps extract has been reported to have various pharmacological activities including an anti-cancer effect. We investigated the inhibitory effect of Cordyceps militaris on hepatitis C virus-infected human hep...
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Article
Phlda3, a urine-detectable protein, causes p53 accumulation in renal tubular cells injured by cisplatin
Measurable indicators of renal injury are required for the assessment of kidney function after toxicant challenge. In our previous study, pleckstrin homology-like domain, family A, member 3 (Phlda3) was a most...
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Article
Genipin as a novel chemical activator of EBV lytic cycle
Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that causes acute infection and establishes life-long latency. EBV causes several human cancers, including Burkitt’s lymphoma, nasopharyngeal and gastr...
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Article
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
Beyond its canonical role in translation, lysyl-tRNA synthetase (KRS) stabilizes the prometastatic 67-kDa laminin receptor (67LR) in the plasma membrane. A small-molecule inhibitor of the KRS-67LR interaction ...
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Article
Inflammatory and microenvironmental factors involved in breast cancer progression
The primary reason for the high mortality rate of breast cancer is metastasis, which can result in a poor survival rate. The tumor environment is important for promotion and invasion of cancer cells. Recent st...
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Article
Editorial note
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Article
Open AccessEpithelial-mesenchymal Transition and Cell Invasion
Epithelial-mesenchymal transition (EMT) is a complex process in which epithelial cells acquire the characteristics of invasive mesenchymal cells. EMT has been implicated in cancer progression and metastasis as...
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Article
The G12 family proteins upregulate matrix metalloproteinase-2 via p53 leading to human breast cell invasion
Although mounting evidence suggests a role for G12 proteins, Gα12 and Gα13, in tumor progression, a direct role of G12 proteins has not been determined. This study aims to elucidate the molecular mechanism for a ...
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Article
Roles of calcium-binding proteins, S100A8 and S100A9, in invasive phenotype of human gastric cancer cells
Gastric cancer is one of the most common malignancies and is a frequent cause of cancer-related death in Korea. Cure rate of gastric cancer is quite low because of local invasion and metastasis. S100 proteins ...
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Article
Differential functions of ras for malignant phenotypic conversion
Among the effector molecules connected with the group of cell surface receptors, Ras proteins have essential roles in transducing extracellular signals to diverse intracellular events, by controlling the activ...
