-
Article
Engineered polysaccharides for controlling innate and adaptive immune responses
Therapeutic interventions can be designed by exploiting the immune system’s ability to initiate specific responses to various stimuli. However, specific T cell activation, which is a key target for vaccines an...
-
Article
Open AccessProtein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease
Population-based association studies have identified many genetic risk loci for coronary artery disease (CAD), but it is often unclear how genes within these loci are linked to CAD. Here, we perform interactio...
-
Article
Open AccessGenoppi is an open-source software for robust and standardized integration of proteomic and genetic data
Combining genetic and cell-type-specific proteomic datasets can generate biological insights and therapeutic hypotheses, but a technical and statistical framework for such analyses is lacking. Here, we present...
-
Article
GeNets: a unified web platform for network-based genomic analyses
Functional genomics networks are widely used to identify unexpected pathway relationships in large genomic datasets. However, it is challenging to compare the signal-to-noise ratios of different networks and t...
-
Article
Open AccessIntegrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders
Integrating rare variation from trio family and case–control studies has successfully implicated specific genes contributing to risk of neurodevelopmental disorders (NDDs) including autism spectrum disorders (...
