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Open AccessAssessment of extremely premature lambs supported by the Extrauterine Environment for Neonatal Development (EXTEND)
Our team has previously reported physiologic support by the EXTra-uterine Environment for Neonatal Development (EXTEND) of 105 to 117 days gestational age (GA) lambs for up to 28 days with normal organ maturat...
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Comment on: Premature delivery in the domestic sow in response to in utero delivery of AAV9 to fetal piglets
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Hirschsprung Disease
Hirschsprung disease, or congenital aganglionosis, may affect some or all of the colon. Patients typically present with constipation early in life. The diagnosis and treatment of Hirschsprung disease have evol...
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Article
Disparities in Stage-Specific Guideline-Concordant Cancer-Directed Treatment for Patients with Pancreatic Adenocarcinoma
The utilization of cancer-directed treatment for patients with all stages of pancreatic cancer in the USA is unknown. This study sought to examine national practice patterns and identify patient, hospital, reg...
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Article
Open AccessIn utero adenine base editing corrects multi-organ pathology in a lethal lysosomal storage disease
In utero base editing has the potential to correct disease-causing mutations before the onset of pathology. Mucopolysaccharidosis type I (MPS-IH, Hurler syndrome) is a lysosomal storage disease (LSD) affecting...
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Gastrointestinal Duplications
Gastrointestinal duplications are rare, most commonly cystic lesions of the gastrointestinal tract which contain well-developed mucosal and smooth muscle layers. The mucosa often resembles the adjacent gastroi...
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Article
Evaluating the ACS NSQIP Risk Calculator in Primary Pancreatic Neuroendocrine Tumor: Results from the US Neuroendocrine Tumor Study Group
In a changing health care environment where patient outcomes will be more closely scrutinized, the ability to predict surgical complications is becoming increasingly important. The American College of Surgeons...
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Article
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Dysfunctional endothelium contributes to more diseases than any other tissue in the body. Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in vivo by durably silencing mult...