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  1. No Access

    Article

    In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat

    The first biological evaluation of two potent fluorine-18 radiolabelled inhibitors of caspase-3/7 was achieved in a cerebral stroke rat model to visualize apoptosis.

    Marie Médoc, Martine Dhilly, Lidia Matesic, Jérôme Toutain… in Molecular Imaging and Biology (2016)

  2. No Access

    Article

    Spectroscopic investigations on the interactions of potent platinum(II) anticancer agents with bovine serum albumin

    The interactions of three platinum(II)-based anticancer complexes [(5,6-dimethyl-1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2+, [(5,6-dimethyl-1,10-phenanthroline)(1R,2R-diaminocyclohexane)platinu...

    Anwen M. Krause-Heuer, William S. Price… in Journal of Chemical Biology (2012)

  3. No Access

    Chapter

    The Synthesis of Platinum(II) Intercalators

    The pharmacological properties of any drug are largely dependent on binding interactions with biomolecules. The investigation of such interactions is essential to gain some understanding of the mechanisms of d...

    Anwen M. Krause-Heuer, Madhura Manohar… in Metallointercalators (2011)

  4. No Access

    Chapter

    Pulsed Gradient Spin-Echo NMR

    Translational diffusion (also referred to as self-diffusion, Brownian motion, or random walks) plays a vital role in all sorts of molecular dynamics in biological systems (e.g., ligand–DNA interactions, lipid–...

    Gang Zheng, Anwen M. Krause-Heuer, William S. Price in Metallointercalators (2011)

  5. No Access

    Article

    Biodegradability of sol–gel silica microparticles for drug delivery

    The biodegradability of porous sol–gel silica microparticles in physiological buffers has been investigated using a USP4 flow-through dissolution tester. In the open configuration, which most closely models in...

    Kim S. Finnie, Daniel J. Waller… in Journal of Sol-Gel Science and Technology (2009)