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Article
In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat
The first biological evaluation of two potent fluorine-18 radiolabelled inhibitors of caspase-3/7 was achieved in a cerebral stroke rat model to visualize apoptosis.
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Article
Spectroscopic investigations on the interactions of potent platinum(II) anticancer agents with bovine serum albumin
The interactions of three platinum(II)-based anticancer complexes [(5,6-dimethyl-1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2+, [(5,6-dimethyl-1,10-phenanthroline)(1R,2R-diaminocyclohexane)platinu...
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Chapter
The Synthesis of Platinum(II) Intercalators
The pharmacological properties of any drug are largely dependent on binding interactions with biomolecules. The investigation of such interactions is essential to gain some understanding of the mechanisms of d...
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Chapter
Pulsed Gradient Spin-Echo NMR
Translational diffusion (also referred to as self-diffusion, Brownian motion, or random walks) plays a vital role in all sorts of molecular dynamics in biological systems (e.g., ligand–DNA interactions, lipid–...
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Article
Biodegradability of sol–gel silica microparticles for drug delivery
The biodegradability of porous sol–gel silica microparticles in physiological buffers has been investigated using a USP4 flow-through dissolution tester. In the open configuration, which most closely models in...