16 Result(s)

Article

Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis

Helminth-derived proteins have immunomodulatory properties, influencing the host’s immune response as an adaptive strategy for helminth survival. Helminth-derived proteins modulate the immune response by induc...

Maimonah Alghanmi, Faisal Minshawi, Tarfa A. Altorki, Ayat Zawawi… in BMC Immunology (2024)

Article

Impact of the SARS-CoV-2 nucleocapsid 203K/204R mutations on the inflammatory immune response in COVID-19 severity

The excessive inflammatory responses provoked by SARS-CoV-2 infection are critical factors affecting the severity and mortality of COVID-19. Previous work found that two adjacent co-occurring mutations R203K a...

Muhammad Shuaib, Sabir Adroub, Tobias Mourier, Sara Mfarrej… in Genome Medicine (2023)

Article

Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer

Triple-negative breast cancer (TNBC) subtype is characterized by aggressive clinical behavior and poor prognosis patient outcomes. Here, we show that ADAR1 is more abundantly expressed in infiltrating breast c...

Najat Binothman, Majidah Aljadani, Bandar Alghanem, Mohammed Y. Refai… in Scientific Reports (2023)

Article

Livelihood activities, human mobility, and risk of malaria infection in elimination settings: a case–control study

Livelihood activities and human movements participate in the epidemiology of vector-borne diseases and influence malaria risk in elimination settings. In Saudi Arabia, where malaria transmission intensity vari...

Shaymaa A. Abdalal, Joshua Yukich, Katherine Andrinopoulos… in Malaria Journal (2023)

Article

Exploring the role of Nrf2 signaling in glioblastoma multiforme

Glioblastoma multiforme (GBM) is one of the most aggressive glial cell tumors in adults. Although current treatment options for GBM offer some therapeutic benefit, median survival remains poor and does not gen...

Wireko Andrew Awuah, Abdul-Rahman Toufik, Rohan Yarlagadda… in Discover Oncology (2022)

Article

SARS-CoV-2 genomes from Saudi Arabia implicate nucleocapsid mutations in host response and increased viral load

Monitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes collected from patients in Saudi Arabia from March...

Tobias Mourier, Muhammad Shuaib, Sharif Hala, Sara Mfarrej… in Nature Communications (2022)

Article

SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients

As the Coronavirus Disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2, continues to spread rapidly around the world, there is a need for well validated serological assays that allow the detection...

Abdullah Algaissi, Mohamed A. Alfaleh, Sharif Hala, Turki S. Abujamel… in Scientific Reports (2020)

Protocol

Quantification of the Middle East Respiratory Syndrome-Coronavirus RNA in Tissues by Quantitative Real-Time RT-PCR

Since the emergence of the Middle East respiratory syndrome-coronavirus (MERS-CoV) in 2012, more than 2280 confirmed human infections and 800 associated deaths had been reported to the World Health Organizatio...

Abdullah Algaissi, Anurodh S. Agrawal, Anwar M. Hashem… in MERS Coronavirus (2020)

Protocol

Qualitative and Quantitative Determination of MERS-CoV S1-Specific Antibodies Using ELISA

Indirect enzyme-linked immunosorbent assay (ELISA) enables detection and quantification of antigen-specific antibodies in biological samples such as human or animal sera. Most current MERS-CoV serological assa...

Sawsan S. Al-amri, Anwar M. Hashem in MERS Coronavirus (2020)

Protocol

Evaluation of MERS-CoV Neutralizing Antibodies in Sera Using Live Virus Microneutralization Assay

The microneutralization (MN) assay is a standard and important technique in virology, immunology, and epidemiology. It is a highly specific and sensitive assay for evaluating virus-specific neutralizing antibo...

Abdullah Algaissi, Anwar M. Hashem in MERS Coronavirus (2020)

Protocol

Generation of MERS-CoV Pseudotyped Viral Particles for the Evaluation of Neutralizing Antibodies in Mammalian Sera

Pseudotyped viral particle production has been used extensively and broadly for many viruses to evaluate levels of neutralizing antibodies, viral entry inhibitors and vaccine immunogenicity. This assay is extr...

Abdulrahman Almasaud, Naif Khalaf Alharbi, Anwar M. Hashem in MERS Coronavirus (2020)

Article

Humoral Immunogenicity and Efficacy of a Single Dose of ChAdOx1 MERS Vaccine Candidate in Dromedary Camels

MERS-CoV seronegative and seropositive camels received a single intramuscular dose of ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV spike protein, with further groups re...

Naif Khalaf Alharbi, Ibrahim Qasim, Abdulrahman Almasoud… in Scientific Reports (2019)

Article

Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein

MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to >25 countries since 2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) in the Arabian Peninsula hig...

Sawsan S. Al-amri, Ayman T. Abbas, Loai A. Siddiq, Abrar Alghamdi… in Scientific Reports (2017)

Article

Complete genome sequencing and phylogenetic analysis of dengue type 1 virus isolated from Jeddah, Saudi Arabia

Dengue viruses (DENVs) are mosquito-borne viruses which can cause disease ranging from mild fever to severe dengue infection. These viruses are endemic in several tropical and subtropical regions. Multiple out...

Esam I Azhar, Anwar M Hashem, Sherif A El-Kafrawy, Said Abol-Ela… in Virology Journal (2015)

Article

A universal monoclonal antibody protects against all influenza A and B viruses by targeting a highly conserved epitope in the viral neuraminidase

Tracey M Doyle, Anwar M Hashem, Changgui Li, Doris J Bucher… in BMC Genomics (2014)