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Open AccessJAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors
Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development an...
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Article
Open AccessSpatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer
To understand the relationship between key non-canonical NF-κB kinase IKK-alpha(α), tumour mutational profile and survival in primary colorectal cancer.
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Article
Open AccessThe Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer
The Glasgow Microenvironment Score (GMS) combines peritumoural inflammation and tumour stroma percentage to assess interactions between tumour and microenvironment. This was previously demonstrated to associat...
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Reply to comment of “ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer”
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Open AccessERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer
In colorectal cancer (CRC), BRAF mutations influence tumour progression. In mismatch repair-deficient (dMMR) tumours, BRAF mutations are associated with a good prognosis, whereas in MMR-competent tumours, they...
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Article
Open AccessNuclear expression of Lyn, a Src family kinase member, is associated with poor prognosis in renal cancer patients
8000 cases of renal cancer are diagnosed each year in the UK, with a five-year survival rate of 50 %. Treatment options are limited; a potential therapeutic target is the Src family kinases (SFKs). SFKs have r...
