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  1. Article

    Open Access

    Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening

    MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportu...

    Zongxiang Zhou, Manishha Patel, Nicholas Ng, Mindy H Hsieh, Anthony P Orth… in BMC Cancer (2014)

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