-
Article
Open AccessBroad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro
A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here we demonstrate that CRISPR-Cas13d offers a broad-spectrum antiviral (BSA) to inhibit many S...
-
Article
Open AccessHyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related...
-
Article
Open AccessHalogenation as a tool to tune antimicrobial activity of peptoids
Antimicrobial peptides have attracted considerable interest as potential new class of antibiotics against multi-drug resistant bacteria. However, their therapeutic potential is limited, in part due to suscepti...
-
Article
Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that t...
-
Article
Open AccessOptimizing Exogenous Surfactant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2
The rising incidence of antibiotic-resistant lung infections has instigated a much-needed search for new therapeutic strategies. One proposed strategy is the use of exogenous surfactants to deliver antimicrobi...
-
Article
Open AccessEffective in vivo treatment of acute lung injury with helical, amphipathic peptoid mimics of pulmonary surfactant proteins
Acute lung injury (ALI) leads to progressive loss of breathing capacity and hypoxemia, as well as pulmonary surfactant dysfunction. ALI’s pathogenesis and management are complex, and it is a significant cause ...
-
Article
Open AccessIntracellular biomass flocculation as a key mechanism of rapid bacterial killing by cationic, amphipathic antimicrobial peptides and peptoids
Many organisms rely on antimicrobial peptides (AMPs) as a first line of defense against pathogens. In general, most AMPs are thought to kill bacteria by binding to and disrupting cell membranes. However, certa...
-
Article
Gene libraries open up
By combining gene cloning and amplification techniques, a new one-pot, parallel synthesis method for the generation of long, repetitive genes is realized. The method promises to open up the discovery of protei...
-
Protocol
Comparing Bacterial Membrane Interactions of Antimicrobial Peptides and Their Mimics
Interactions with bacterial membranes are integral to the mechanisms of action of all antimicrobial peptides (AMPs), regardless of their final cellular targets. Here, we describe in detail two biophysical tech...
-
Article
Open AccessExperimental and theoretical investigation of chain length and surface coverage on fouling of surface grafted polypeptoids
Numerous strategies exist to prevent biological fouling of surfaces in physiological environments; the authors’ strategy focuses on the modification of surfaces with poly-N-substituted glycine oligomers (polypept...
-
Chapter
Influence of Polymer Concentration and Electric Field Experimental Study and Comparison with Theory
DNA molecules cannot be separated by free-solution electrophoresis [1], because in free solution the ratio of net molecular charge to friction coefficient (the electrophoretic mobility) is nearly equal for all...
