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  1. No Access

    Article

    Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome

    Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics underlying this transformation, we c...

    Erin M. Parry, Ignaty Leshchiner, Romain Guièze, Connor Johnson… in Nature Medicine (2023)

  2. No Access

    Article

    Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

    Neoantigens, which are derived from tumour-specific protein-coding mutations, are exempt from central tolerance, can generate robust immune responses1,2 and can function as bona fide antigens that facilitate tumo...

    Derin B. Keskin, Annabelle J. Anandappa, **g Sun, Itay Tirosh… in Nature (2019)