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Article
Open AccessTowards machine learning-based quantitative hyperspectral image guidance for brain tumor resection
Complete resection of malignant gliomas is hampered by the difficulty in distinguishing tumor cells at the infiltration zone. Fluorescence guidance with 5-ALA assists in reaching this goal. Using hyperspectral...
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Article
Open AccessProtoporphyrin IX in serum of high-grade glioma patients: A novel target for disease monitoring via liquid biopsy
High-grade gliomas (HGG) carry a dismal prognosis. Diagnosis comprises MRI followed by histopathological evaluation of tissue; no blood biomarker is available. Patients are subjected to serial MRIs and, if unc...
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Article
Open AccessChallenges in, and recommendations for, hyperspectral imaging in ex vivo malignant glioma biopsy measurements
The visualization of protoporphyrin IX (PPIX) fluorescence with the help of surgical microscopes during 5-aminolevulinic acid-mediated fluorescence-guided resection (FGR) of gliomas is still limited at the tum...
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Article
Open AccessCharacterization of autofluorescence and quantitative protoporphyrin IX biomarkers for optical spectroscopy-guided glioma surgery
5-Aminolevulinic acid (5-ALA)-mediated fluorescence does not effectively depict low grade gliomas (LGG) or the infiltrative tumor portion of high-grade gliomas (HGG). While spectroscopy improves sensitivity an...
