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Article
Open AccessVitamin C boosts DNA demethylation in TET2 germline mutation carriers
Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose...
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Chapter and Conference Paper
Using Minimum Path Cover to Boost Dynamic Programming on DAGs: Co-linear Chaining Extended
Aligning sequencing reads on graph representations of genomes is an important ingredient of pan-genomics. Such approaches typically find a set of local anchors that indicate plausible matches between substrings o...
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Article
Open AccessA novel min-cost flow method for estimating transcript expression with RNA-Seq
Through transcription and alternative splicing, a gene can be transcribed into different RNA sequences (isoforms), depending on the individual, on the tissue the cell is in, or in response to some stimuli. Rec...
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Chapter and Conference Paper
A Novel Combinatorial Method for Estimating Transcript Expression with RNA-Seq: Bounding the Number of Paths
RNA-Seq technology offers new high-throughput ways for transcript identification and quantification based on short reads, and has recently attracted great interest. The problem is usually modeled by a weighted...
